Pharmaceutical compositions for topical application

Details Pharmaceutical compositions for topical application Pharmaceutical compositions for topical application

1996-10-24

1997-11-04

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424447, 424448, 514946, 514947, 514618, 514706, 514458, A61F 1300

Patent

active

056837135

ABSTRACT:
A pharmaceutical and cosmetical preparation which rapidly penetrates through human skin, and which thus is able to bring about the rapid transdermal penetration of a wide variety of active ingredients. The compounds which enhance the rate of dermal penetration are also anti-oxidative agents and thus protect active substances susceptible to oxidative degradation. Preferred agents enhancing penetration and which protect against oxidation are higher esters and higher amides of thioglycolic acid and of mercaptopropionic acid. The preparations can be in the form of mixtures or there may be prepared chemical compounds which are a combination of the active substance and the said thioacids.

REFERENCES:
patent: 4195095 (1980-03-01), Sheffner
patent: 4246278 (1981-01-01), Opitz et al.
patent: 4380549 (1983-04-01), Van Scott
patent: 4690683 (1987-09-01), Chien
patent: 5091171 (1992-02-01), Yu
"Application of Calcium Thioglycolate to Improve Transdermal Delivery of Theophylline in Rats," by Kazuo Kushida et al., Chem. Pharm. Bull., vol. 32, 1984, pp. 268-274.

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