Pharmaceutical compositions for the treatment of pain

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S725000, C424S725000

Reexamination Certificate

active

07968594

ABSTRACT:
The present invention relates to treatment of cancer related pain and constipation. Preferably the subject in need is administered a combination of the cannabinoids cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC). More preferably the cannabinoids are in a predefined ratio by weight of approximately 1:1 of CBD to THC.

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The United Kingdom Parliament, Select Committee on Science and Technology Ninth Report (1998) at http://www.parliament.the-stationery-office.co.uk/pa/ld199798/Idselect/Idsctech/151/15101.htm.
The United Kingdom Parliament, Select Committee on Science and Technology Second Report (Mar. 14, 2001) at http://www.publications.parliament.uk/pa/Id200001/ldselect/Idsctech/50/5001.htm.
GW Pharmaceuticals News Release, “GW Announces Positive Preliminary Results with its Cannabis-based Medicine (Sativex®) in Phase III Cancer Pain Trial,” dated Jan. 19, 2005.
Cleeland , C.S. et al., “Quality Improvement Guidelines for the Treatment of Acute Pain and Cancer Pain,”JAMA1995; 274(23): 1874-80.
Formukong, E.A. et al., “Analgesic and Antiinflammatory Constituents ofCannabis salivaL.,”Inflammation1988; 12(4): 361-371.
Holdcroft, A. et al., “Clinical Trial Experience with Cannabinoids,”Pharmaceutical Sciences1997; 3: 546-550.
Holdcroft, A. et al., “Pain relief with oral cannabinoids in familial Mediterranean fever,”Anaesthesia1997; 52: 483-486.

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