Pharmaceutical compositions for the treatment of hereditary tyos

Details Pharmaceutical compositions for the treatment of hereditary tyos Pharmaceutical compositions for the treatment of hereditary tyos

1994-12-19

1996-08-27

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

A61K 3112

Patent

active

055501656

ABSTRACT:
The invention concerns novel pharmaceutical compositions containing as an active ingredient a 2-benzoyl-1,3-cyclohexanedione which is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD). The compositions are valuable in the treating those disorders and diseases in which it is desirable to intervene in the metabolic sequences catalysed by HPPD, such as in treating tyrosinemia type I.

REFERENCES:
patent: 4774360 (1988-09-01), Bay
patent: 4780127 (1988-10-01), Michaely et al.
J. Pediatr Gastroenterol Nutr. vol. 17, No. 3, 1993.
Lancet 1992; vol. 340, 813-817, Oct. 1992.
International Preliminary Report of PCT/GB92/01094, 1993.
International Search Report of PCT/GB92/01094, 1992.

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