Pharmaceutical compositions for oral use and method of preparing

Details Pharmaceutical compositions for oral use and method of preparing Pharmaceutical compositions for oral use and method of preparing

1992-11-18

1996-07-09

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514381, 5147723, 5147724, A61K 31415

Patent

active

055345344

ABSTRACT:
A pharmaceutical composition for oral use comprising an effective amount of a compound of the formula (I) having antagonistic action to angiotensin II ##STR1## (wherein the ring W is an optionally substituted N-containing heterocyclic residue; R.sup.3 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2) and an oily substance having a lower melting point, and a method for preparing a pharmaceutical composition for oral use comprising an effective amount of a compound of the formula (I) and an oily substance having a lower melting point, which comprises admixing the compound of the formula (I) with an oily substance having a lower melting point and then subjecting the mixture to molding.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5128356 (1992-07-01), Naka
Seta et al., "Preparation and pharmacological evaluation of captopril sustained-release dosage forms using oily semisolid matrix", International Journal of Pharmaceuticals, vol. 413 1988, pp. 255-262.
JP-B-57-45206/1982.
Remington's Pharmaceutical Sciences, 17th Edition Alfonso Gennaro Ed., pp. 1305; 1306, 1478-1480; 653-666 (1985).
Handbook of Pharmaceutical Excipients, American Pharmaceutical Assoc. 1986, ISBN (U.S.) 0-917 330-56-0. p. 213.

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