Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1984-02-29
1987-11-03
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
435178, 435194, 536 22, 536 29, C12N 996, C12N 1110, C12N 912, C07H 1910
Patent
active
047043610
ABSTRACT:
The invention relates to pharmaceutical compositions for use in the therapy of pathological states related to disturbances of the nervous stimulus in the central (CNS) and peripheral (PNS) nervous system containing as an active substance the cytidine monophosphate of 5-acetamido-3,5-dideoxy-D-glycero-D-galactononulosaminic acid. Moreover the invention relates to an improved method for preparing said compound by the condensation of cytidine triphosphate (CTP) with N-acetylneuraminic acid (NANA), catalyzed by the enzyme CMP-transferase (CMP-acylneuraminate synthase) (EC 2.7.7.43).
REFERENCES:
patent: 4118279 (1978-10-01), Determann et al.
Corfield, et al., "The Preparation of CMP-Sialic Acids by Using CMP-Acylneuraminate Synthese from Frog Liver Immobilized on Sepharose 4B", Biochem. J., (1979), pp. 1-7.
Decorte Enio
Miccoli Pietro
Compagnia di Ricerca Chimica S.p.A.
Mays Thomas D.
Wiseman Thomas G.
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