Pharmaceutical compositions containing superoxide dismutase from

Details Pharmaceutical compositions containing superoxide dismutase from Pharmaceutical compositions containing superoxide dismutase from

1995-05-22

1998-06-30

Kemmerer, Elizabeth C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Oxidoreductases

435192, 4352525, A61K 3844, C12N 908, C12N 1563

Patent

active

057729964

ABSTRACT:
A pharmaceutical composition for use in the prophylaxis or treatment of pathological conditions resulting from the presence of superoxide radicals, comprising a manganese-superoxide dismutase (MnSOD) enzyme and a pharmaceutically acceptable excipient. The MnSOD enzyme is in native form and has substantially the amino acid sequence of SEQ ID NO: 17 or SEQ ID NO: 29 and is free of pyrogens consisting of macromolecular substances native to Bacillus Stearothermophilus (BS) or Bacillus Caldotenax (BC). Processes for producing the novel pharmaceutical composition and a method for the prophylaxis or treatment of pathological conditions resulting from the presence of superoxide radicals utilizing the novel composition are also disclosed.

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