Pharmaceutical compositions containing propylene glycol and/or p

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514557, 514738, A61K 3117, A61K 3119, A61K 31045

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active

055256350

ABSTRACT:
Composition active for the treatment of hyperkeratotic skin diseases, seborrheic eczema, dermatomycosis and onychomycosis, thickened skin and chapped skin, containing propylene glycol and/or polyethylene glycol and urea as active main components and optionally other active substances and additives, which composition is characterized in that it contains 40-80% by weight propylene glycol and/or polyethylene glycol, 5-20% by weight urea and 0-55% by weight of other active substances and/or additives; as well as the use thereof.

REFERENCES:
patent: 3395236 (1968-07-01), White
patent: 3666863 (1972-05-01), Swanbeck
Patent Abstracts of Japan, abstract of JP Kokai No. 52-87235, published 20 Jul. 1977.
Karnan, vol. 9, No. 1, issued 1985 (AB Leo, Helsingborg, Sweden), J. Faergemann, "Pityriasis versicolor, Orsak, diagnos och behandling", see pp. 13-17, especially p. 13, left column, third paragraph and p. 17, left column, second paragraph.
Zaias Onychomycosis. Arch Derm. 1972; 105: 263-74.
Ishii M. Hamada I, Asai Y. Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment. Dermatologica 1983; 167: 273-9.
Priestley G. C. Savin J. A. The microbiology of dandruff. Br J Dermatol 1976; 94: 469-71.
Shuster S. The aetiology of dandruff and the mode of action of therapeutic agents. Br J. Dermatol 1984; III: 235-42.
Nielson P. G. The importance of the vehicle in the treatment of dermatophytosis in hereditary palmo-planter keratoderma. Mykosen 1984; 27 (5):227-30.
Gamborg Nielsen P. Dermatophyte infections in hereditary palmo=plantar keratoderma. Dermatologica 1984; 168: 238-41.
Faergemann J. Fredriksson I. Propylene glycol in the tretment of tinea versicolar. Acta Derm Venereol 1979; 60:92-3.
Faergemann J. Bernader S. The activity in vitro of five different anti-mycotics against pityrosporum orbiculare. Acta Derm Venereol 1979; 59: 521-4.
Leyden J. J. Stewart R, Kligman A. M. Updated in vivo methods of evaluating topical antimicrobial agents on human skin. J. Invest Dermatol 1979; 72: 165-70.
Martindale, The extra pharmacopoeia, Ed. 28, 1982.
Bagatell F. K. Topical therapy for onychomycosis. Arch Derm 1977; 113: 378.
Ashton H. Frenk E, Stevenson C. J. Urea as a topical agent. Br. J. Dermatol 1970; 84: 194-6.
Farber E. M., South D. A. Urea ointment in the nonsurgical avulsion of nail dystrophies. Cutis 1978; 22: 689-92.
South D. A., Farber E. M. Urea ointment in the nonsurgical avulsion of nail dystrophies.--a reappraisal. Cutis 1980 25: 609-12.
Nolting S. Non-traumatic removal of the nail and simultaneous treatment of onychomycosis. Dermatologica 1984; 169 (suppl. 1): 117-20.
English language abstract of German Patent DE 2608221, 1977.

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