Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1996-10-08
1998-01-06
Krass, Frederick
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424 9411, 424 94, 424495, 424499, 514718, 514975, A61K 706, A61K 7135
Patent
active
057051941
ABSTRACT:
There is disclosed a pharmaceutical composition which gels at physiological temperature. The composition is comprised of a block copolymer containing one or more polyoxyethylene blocks and one or more polyoxy (higher alkylene) blocks wherein at least some of the blocks are linked together by a linking group characterised in that the linking group is an oxymethylene group, and a therapeutic agent. The therapeutic agent is present as (i) nanoparticles of the therapeutic agent having the block copolymer adsorbed on the surface thereof, (ii) a suspension in a solution of the block copolymer, or (iii) as an aqueous solution in a solution of the block copolymer.
REFERENCES:
patent: 3740421 (1973-06-01), Schmolka
patent: 3867533 (1975-02-01), Schmolka
patent: 4465663 (1984-08-01), Schmolka
patent: 4587365 (1986-05-01), Anchor
Chemical Abstracts 117:151640, "High Molecular Weight Polyetherpolyols".
Cooper Eugene R.
Wong Sui-Ming
Xu Shuqian
Krass Frederick
NanoSystems L.L.C.
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