Pharmaceutical compositions containing paracetamol

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 12, 424 22, 424 32, 424 33, 424 35, 424 37, 424 38, 424280, 424324, A61K 922, A61K 952, A61K 31165, A61K 31375

Patent

active

042922984

ABSTRACT:
The acute liver toxicity effects of paracetamol are reduced by co-formulating with sustained release ascorbic acid which produces high liver concentrations of ascorbate anion after oral administration of the co-formulation. A suitable form of sustained release ascorbic acid is prepared by microencapsulation of particles of ascorbic acid in membranes which act as microdialysis cells.

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Raghuram et al., Toxicol. Lett. 1978 2(3): 175-178, Effect of Vitamin C on Paracetamol Hepatotoxicity.
Subaschandran et al., Poultry Sci. 46(5): 1073-6 (1967), Acetyl-p-aminophenol and Vitamin C in Heat Stressed Birds.
Sacharin Int. J. Vitamin Nutr. Res. (1977) 47(1): 68-74, Blood Levels and Bioavailability of Ascorbic Acid After Adm. of a Sustained Release Formulation to Humans.
Kassem, Bull. Fac. Pharm., Cairo U., 1973, Pub. 1975, 12(2): 11-24, Microencapsulation of L-Ascorbic Acid.

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