Pharmaceutical compositions containing non-steroidal anti-inflam

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai

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514162, 514408, 514420, A61K 3140, A61K 3160, A61K 31615

Patent

active

049702025

ABSTRACT:
A pharmaceutical composition for treating an inflammatory condition contains a non-steroidal anti-inflammatory drug (NSAID) and a physiologically acceptable aromatic hydroxysulphonic acid. The two components may be for simultaneous, separate or sequential use. Administration of the two components, for example of aspirin with ethamsylate, reduces the damage which the NSAID does to the gastrointestinal tract while having no deleterious effect on the anti-inflammatory activity.

REFERENCES:
Chem. Abst. (91)-117449y (1979).
Chem. Abst.(95)-126013m (1981).
Chem. Abst.(106)-149146S 1987.
Dayrene, P., et al., "Antiinflammatory and Immunostimulant Activities of Six Sulphur Compounds-Four Benzenesulphonates, Levamisole, and Pyritinol Hydrochloride Assayed In Mouse Cell Activation Studies," Arzneim-Forsch/Drug Res., 33, (I), 3 (1983), 372-377.
Dew, M. J., et al. "Maintenance Therapy for Duodenal Ulcer-a Trial Comparing Cimetidine with a Prostaglandin Synthetase Promoter." Journal of Clinical and Hospital Pharmacy, 9, (1984), 357-359.
Nagasubramanian, S. "The Effects of Ethamsylate and Calcium Dobesilate on the Outflow Facility and Intracular Pressure." Excerpta Medica I. C. S. (the Netherlands), 2/450 (1983), 1480-1484.
Extra Pharmacopoeia Martindale 28th Edition p736 (No. 1720p).
Extra Pharmacopoeia Martindale 28th Edition P1688 (No. 12506M).
Michal et al.: "Effect of Calcium Dobesilate and Its Interaction With Aspirin on Thrombus Formation In Vivo", Thrombosis Research, 40; 215-226, 1985.
Michielotto et al.: "Studio della coagulazione e dell'emostasi in soggetti trattati con ciclonamina", Gazzetta Internazionale di Medicina e Chirurgia, Anno LXXI, vol. LXXII, No. 13, 1967.
Kotarba, Andrej: "Some Clinical Findings Relative to the Efficacity and Therapeutic Indications of a New Hemostatic: Dicynone", Acad. Med., Comm. Pers. Warsaw (1963).
Prato et al.: "Clinical Research and Experimental Findings on the Antihaemorrhagic Activity of Cyclohexadioenoline (Dicynene)", Minera Med., 59, Suppl. No. 28:1653-1657 (1968).
Esteve et al.: "Cyclonamine (141-E) et agents hemorragipares", Soc. Espanola Cienc. Fisiol., 5ieme Reunion Nationale, Madrid, Dec. 1959.
Whittle et al., "A Biochemical Basis for the Gastrointestinal Toxicity of Non-steroid Antirheumatoid Drugs", Arch. Toxicol., Supple. 7, 315-322 (1984). Toxicol.
Keat et al.: "Adverse GI Tract Reactions to Antirheumatic Drugs", Update, 15 Jun. 1985.
Dew: "Maintenance Therapy for Duodenal Ulcer-a Trial Comparing Cimetidine with a Prostaglandin Synthetase Promoter", Journal of Clinical and Hospital Pharmacy (1984) 9, 357-359.
Brooks et al.: "Non-Steroidal Anti-Inflammatory Drugs", Clinical Pharmacology of Anti-Inflammatory Compounds, Chapter 5, 59-85.
Hutton et al.: "Studies on the Action of Ethamsylate (Dicynene) on Haemostasis", Thrombosis and Haemostasis, 56(1), 6-8 (1986).

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