Pharmaceutical compositions containing nanocapsules

Details Pharmaceutical compositions containing nanocapsules Pharmaceutical compositions containing nanocapsules

1994-01-10

1996-03-19

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

264 41, 4284022, 42840221, 424455, 424489, 514806, 514808, 514939, 514943, 514951, A61K 951

Patent

active

055002242

ABSTRACT:
A pharmaceutical composition in the form of a colloidal suspension of nanocapsules, comprising an oily phase consisting essentially of an oil containing dissolved therein a surfactant and suspended therein a plurality of nanocapsules having a diameter of less than 500 nanometers, said nanocapsules encapsulating an aqueous phase consisting essentially of a solution or a suspension of a therapeutically active substance, a surfactant and optionally ethanol; a process for preparing the said composition is also described. The walls of said nanocapsules are formed from a poly(alkyl 2-cyanoacrylate) wherein the alkyl radical has 1 to 6 carbon atoms. This composition is particularly suitable for oral administration of polypeptides and polysaccharides.

REFERENCES:
Michel et al., Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 18th, 970-8 Edited by: Kellaway, Ian W., Controlled Release Soc.: Deerfield, Ill. Jan. 1991.

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