Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1992-11-05
1996-05-21
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514912, A61K 31215
Patent
active
055190545
ABSTRACT:
Pharmaceutical compositions for the treatment of cataract containing N-acetyl-L-cysteine derivatives of formula ##STR1## (wherein R and R.sub.1 have the meanings reported in the specification) are described.
REFERENCES:
Chemical Abstract 109:93608m (1988). Sato et al.
Kahns, et al "Prodrugs As Drug Delivery Systems; 107; Synthesis and Chemical and Enzymatic Hydrolysis Kinetics of Various Mono- and Diester Prodrugs of N-Acetylcysteine," International Journal of Pharmaceutics, 62, (1990) pp. 193-205.
"An in Vitro Model for Determination of Drug Permeability Through the Cornea." Acta Pharmaceutics 22, (1985) pp. 335-342.
Camber, et al "Influence of Some Preservatives on the Corneal Permeability of Pilocarpine and Dexamethasone, in Vitro," International Journal of Pharmaceutics 39, (1987) pp. 229-234.
The Merck Index 11th Ed., "Encyclopedia of Chemicals, Drugs, and Biologicals," No. 82, Acetyleysteine (1989) p. 14.
Chemical Abstract No. 86:115832 vol. 86, (1977) p. 99.
Derwent File Supplier, Derwent Publications Ltd, JP-A-56 147,715, (1991).
Jose Ferrer, et al "Age-Related Changes in Glutathione Synthesis in the Eye Lens" The Biochemical Journal vol. 269, No. 2, (1990) pp. 531-534.
Anne H. Kahns et al "Prodrugs as Drug Delivery Systems. 1-7. Synthesis and Chemical and Enzymatic Hydrolysis Kinetics of Various Mono-and Diester Prodrugs of N-Acetylcysteine" International Journal of Pharmaceutics vol. 62 Nos. 2, 3, (1990) pp. 193-205.
Chemical Abstract No. 63608M, vol. 109, (1988) p. 774.
Kahns et al. Internal. J. Pharmaceutics, 62, 100 2, 3, 1990, p. 193.
Design of Biopharmaceutical Properties Through Prodrugs and Analogs. (1978), Roche.
Bertolini Giorgio
Casagrande Cesare
Gazzaniga Annibale
Pellacini Franco
Santangelo Francesco
Fay Zohreh
Zambon Group S.p.A.
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