Pharmaceutical compositions containing low molecular weight derm

Details Pharmaceutical compositions containing low molecular weight derm Pharmaceutical compositions containing low molecular weight derm

1996-12-12

1998-10-06

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 56, 514822, A61K 31715, A61K 31725

Patent

active

058176454

ABSTRACT:
The prevention and therapy of pulmonary embolism with pharmaceutical compositions containing low molecular weight dermatan sulfate is described. These pharmaceutical compositions are administered by subcutaneous, intramuscular or intravenous route at a daily dosage between 200 and 3000 mgs of active principle. The low molecular weight dermatan sulfate preferred in carrying out the invention has an average molecular weight equal to 5500.+-.1100 Daltons and is obtained by depolymerization of the dermatan sulfate of natural origin in the presence of hydrogen peroxide and cupric ions.

REFERENCES:
patent: 4973580 (1990-11-01), Mascellani et al.
patent: 5164378 (1992-11-01), Conti et al.
patent: 5252339 (1993-10-01), Cristofori et al.
patent: 5576304 (1996-11-01), Kakkar et al.
patent: 5763427 (1998-06-01), Weitz et al.
Bergqvist et al. Glycosaminoglycans in Prophylaxis Against Venous Thromboembolism. Advances in Experimental Medicine & Biology. vol. 313, pp. 259-274. (1992).
Cohen et al. A Dose Ranging Study of Evaluate Dermatan Sulphate in Preventing Deep Vein Thrombosis Following Total Hip Arthroplasty. Thrombosis and Haemostasis. 72(6), pp. 793-798.(1994).
Charbonnier et al. Anticoagulant Therapy in Pulmonary Embolism. Archives des Maladies du Coeur et des Vaisseaux. vol. 88, No. 11(supplemental), pp. 1755-1761. (Nov. 1995).
Gent et al. Low-Molecular Wt. Heparinoid Orgaran is More Effective Than Aspirin in the Prevention of Venous Thromboembolism After Surgery for Hip Fracture. Circulation. 93(1), pp. 80-84. (Jan. 1996).

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