Pharmaceutical compositions containing isoquinoline derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514309, 514265, A61K 3147, A61K 3152

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active

055568629

ABSTRACT:
Pharmaceutical compositions containing an isoquinoline derivative exhibit an excellent inhibitory action to an isozyme of phosphodiesterase of the type IV (PDEIV). The active component of the pharmaceutical composition is an isoquinoline derivative which is represented by the general formula: ##STR1## wherein R is an ethoxy group, or which is a pharmaceutically-acceptable salt of a compound represented by said formula. The isoquinoline derivatives have an excellent inhibitory action which is highly specific to PDEIV. They are highly useful as pharmaceuticals such as antidepressive agents, tranquilizers, antidemential agents, antiinflammatory agents, antiallergic agents, antiasthmatic agents, liver-protecting agents, and diuretic agents.

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patent: 4820838 (1989-04-01), Freisz et al.
patent: 4956371 (1990-09-01), Shoupe et al.
Piskarev et al, Biological Abstracts, vol. 68, No. 3, Abstract No. 18993, 1979.
Lugnier et al, Chemical Abstracts, vol. 117, No. 9, abstract No. 85778s, 1992.
Lugnier et al, Pharmazie, vol. 47, No.1, 1992, pp. 46-49.

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