Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1984-05-09
1986-04-01
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 32, 424 35, 514 3, A61K 950, A61K 928, A61K 3726
Patent
active
045797307
ABSTRACT:
The invention provides a pharmaceutical composition for the oral administration of insulin comprising insulin, a bile acid or alkali metal salt thereof, the bile acid being selected from the group consisting of cholic acid, chenodeoxycholic acid, taurocholic acid, taurochenodeoxycholic acid, glycocholic acid, glycochenocholic acid, 3.beta.-hydroxy-12-ketocholic acid, 12.alpha.-3.beta.-dihydrocholic acid, and ursodesoxycholic acid, and a protease inhibitor, the composition being provided with an enterocoating to assure passage through the stomach and release in the intestine.
REFERENCES:
Sarrach Stud. Biophys 100(2):95-102 (1984).
Leung et al., Artif. Organs 7(2): 208-212 (1983).
Chang, J. Bioeng. 1(1):25-32 (1976).
Ziv et al., Life Sci. 29(8):803-809 (1981).
Bar-On Hanoch
Eldor Amiram
Kidron Miriam
Ziv Ehud
Hadassah Medical Organization
Rose Shep K.
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