Pharmaceutical compositions containing cytidine monophosphate of

Details Pharmaceutical compositions containing cytidine monophosphate of Pharmaceutical compositions containing cytidine monophosphate of

1990-07-23

1991-12-03

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514824, 514907, A61K 3170

Patent

active

050700790

ABSTRACT:
The invention relates to pharmaceutical compositions for use in the therapy of pathological states related to disturbances of the nervous stimulus in the central (CNS) and peripheral (PNS) nervous system containing as an active substance the cytidine monophosphate of 5-acetamido-3,5-dideoxy-D-glycero-D-galactono-nulosaminic acid. Moreover the invention relates to an improved method for preparing said compound by the condensation of cytidine triphosphate (CTP) with N-acetylneuraminic acid (NANA), catalyzed by the enzyme CMP-transferase (CMP-acylneuraminate synthase) (EC 2.7.7.43).

REFERENCES:
patent: 4100271 (1978-07-01), Krezanoski
patent: 4593091 (1986-06-01), della Valle et al.
Hultsch et al., Chem. Abst. 77:57997z, 1972.
Corfield et al., Chem. Abst. 91:86110z, 1979.

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