Pharmaceutical compositions containing cardiac glycoside

Details Pharmaceutical compositions containing cardiac glycoside Pharmaceutical compositions containing cardiac glycoside

1976-12-01

1978-01-10

Rosen, Sam

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424182, A61K 948, A61K 31705

Patent

active

040679608

ABSTRACT:
A cardiotonic dosage unit form comprises a soft gelatine capsule containing a liquid cardiotonic composition comprising (a) a cardiac glycoside, preferably digitoxin or digoxin; (b) dimethyl formamide or dimethyl acetamide; and (c) a liquid polyethylene glycol and also, optionally, (d) propylene glycol or glycerin.
The weight ratio of dimethyl acetamide or dimethyl formamide to cardiac glyceride is preferably at least 5:1 and the polyethylene glycol preferably forms at least 75% by weight of the total composition contained in the gelatine capsule.

REFERENCES:
patent: 2298122 (1942-10-01), Hailer et al.
patent: 2990333 (1961-06-01), Graham
patent: 3472931 (1969-10-01), Stoughton
Chiou et al., Chem. Abst., vol. 75, (1971), pp. 143,955z.

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