Pharmaceutical compositions containing camptothecins

Details Pharmaceutical compositions containing camptothecins Pharmaceutical compositions containing camptothecins

2011-08-09

2011-08-09

Krass, Frederick (Department: 1612)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S051000

Reexamination Certificate

active

07994186

ABSTRACT:
A camptothecin-containing pharmaceutical composition which contains: (a) camptothecin or a derivative thereof, and (b) one or more compounds selected from among ascorbic acid or a salt thereof, sodium hydrogen sulfite, sodium sulfite, potassium pyrosulfite, sodium erythorbate, sodium thioglycolate, sodium pyrosulfite, and α-thioglycerin. The pharmaceutical composition is useful in that, after storage for a long period of time or under light-irradiation conditions, camptothecin or a derivative thereof contained therein undergoes minimum degradation.

REFERENCES:
patent: 4473692 (1984-09-01), Miyasaka et al.
patent: 4545880 (1985-10-01), Miyasaka et al.
patent: 4604463 (1986-08-01), Miyasaka et al.
patent: 4948788 (1990-08-01), Makino et al.
patent: 5061714 (1991-10-01), Tadokoro et al.
patent: 5122526 (1992-06-01), Wall et al.
patent: 5468754 (1995-11-01), Hausheer et al.
patent: 5942386 (1999-08-01), Kmiec et al.
patent: 6287602 (2001-09-01), Singh
patent: 6476043 (2002-11-01), Toutain et al.
patent: 2002/0035091 (2002-03-01), Govindarajan et al.
patent: 62-47193 (1987-10-01), None
patent: 3-4077 (1991-01-01), None
patent: 7-277981 (1995-10-01), None
patent: 10-17472 (1998-01-01), None
patent: 2003-073751 (2003-03-01), None
patent: 2004-277374 (2004-10-01), None
Katsuya Akimoto, et al., “Kinetic Studies of the Hydrolysis and Lactonization of Camptothecin and Its Derivatives, CPT-11 and SN-38, in Aqueous Solution”, Chem. Pharm. Bull. vol. 42. No. 10, Oct. 1994, pp. 2135-2138.
Katsuya Akimoto, et al., “Photodegradation reactions of CPT-II, a derivative of camptothecin. I: chemical structure of main degradation products in aqueous solution”, Drug Stability, vol. 1, No. 2, 1996, pp. 118-122.
U.S. Appl. No. 10/586,879, filed Jul. 21, 2006, Nakazawa, et al.

Affiliated with

Also associated with

Rating

Pharmaceutical compositions containing camptothecins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical compositions containing camptothecins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions containing camptothecins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2774387