Pharmaceutical compositions containing biodegradable polymers

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only

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424 81, 424250, 424261, 424361, A61K 3174, A61K 3178

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active

044514522

ABSTRACT:
Polymers formed by incomplete esterification of the hydroxy groups of a water-soluble polymer such as polyvinyl alcohol, amylose or dextran with a pharmacologically acceptable mono- or di-carboxylic acid to an extent sufficient to render the polymer water-insoluble although still water-swellable, are biodegradable. They are useful for the formulation of pharmaceutical compositions for parenteral administration, particularly in the form of injectable fine particles in which a drug is intimately mixed with or encapsulated by the polymer.

REFERENCES:
patent: 3081233 (1963-03-01), Enz et al.
patent: 3499962 (1970-03-01), Wurzburg et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 3978203 (1976-08-01), Wise
patent: 4209513 (1980-06-01), Torode et al.
Merck Index, 9th ed., 1976, pp. 386, 387 & 986, para. 2904 & 7363.
Webster's Seventh New Collegiate Dictionary, p. 31, 1967.
Chemical Abstracts 79:79306s, (1973).
Chemical Abstracts 81:170012v, (1974).
"Kexikon der Hilfsmittel", Fiedler, 2nd Edn., 1981.

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