Pharmaceutical compositions containing acylated benzilic acid de

Details Pharmaceutical compositions containing acylated benzilic acid de Pharmaceutical compositions containing acylated benzilic acid de

1990-03-19

1991-09-10

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514906, 546222, A61K 31445, C07D21136

Patent

active

050474138

ABSTRACT:
Certain acylated benzilic acid derivatives are useful for influencing therapeutically the tone of the urinary bladder in humans and animals. These derivatives are N-alkyl-4-piperidyl .alpha.,.alpha.-diphenyl-.alpha.-acyloxyacetates having the formula ##STR1## wherein R is H, CH.sub.3, C.sub.2 H.sub.5 or C.sub.3 H.sub.7 ; R' is H, NH.sub.2, phenyl, carboxyphenyl, (C.sub.1 -C.sub.6)alkyl, hydroxy(C.sub.1 -C.sub.6)alkyl, methoxy, ethoxy, methoxymethyl, ethoxymethyl, amino(C.sub.1 -C.sub.6)alkyl which can be substituted in the alkyl radical by one or more of a --NH.sub.2, --COOH or --SCH.sub.3 group, N-acetylamino(C.sub.1 -C.sub.6)alkyl, or a group having the formula

REFERENCES:
patent: 2918406 (1959-12-01), Biel
patent: 4022787 (1977-05-01), Soldati et al.

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