Pharmaceutical compositions consisting or consisting essentially

Details Pharmaceutical compositions consisting or consisting essentially Pharmaceutical compositions consisting or consisting essentially

1980-01-14

1984-07-17

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424 79, 424251, A61K 3170, A61K 3174, A61K 31505

Patent

active

044605773

ABSTRACT:
A method is disclosed for purifying non-homogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic and organic nature having chemical functionality, which are used as ion-exchangers. The liquid or solid polymers are based on styrene, divinylbenzene, acrylic acid, methacrylic acid, and the like, normally known as ion-exchange resins, and may include carboxylic, phosphonic, or sulphonic functions of different matrices. The ion-exchange resins may also include salified quaternary ammonium, primary, secondary and tertiary amminic or phosphinic functions or other functions with different matrices, including phenolformaldehyde, styrene-divinylbenzene, acrylates, methacrylates, hydrocarbons and condensation-resins. Treatment may also be carried out with polymers, copolymers, or mixtures thereof, not having any specific chemical function and which normally, but not exclusively, react according to Van der Waals' forces, commonly known as adsorbents. The invention also includes pharmaceutical compositions consisting or consisting essentially of lyophilic liposomes of doxorubicin hydrochloride, aminosidine sulphate or 5-fluoro-uracil.

REFERENCES:
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Tyrrell, Biochem. & Biophys. Acta, vol. 457, 1976, pp. 259-274.
Tritton, Biochem. & Biophys. Res. Comm., vol. 84, 1978, pp. 802-808.
Merck Index, 9th Ed., 1976, No. 3428.
Segal, Clin. Sci. & Molecular Med., vol. 49, 1975, pp. 99-106.

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