Pharmaceutical compositions consisting of acylated phospholipids

Details Pharmaceutical compositions consisting of acylated phospholipids Pharmaceutical compositions consisting of acylated phospholipids

1986-07-21

1991-01-08

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 436829, 514 34, 514974, A61K 952, B01J 1302

Patent

active

049833979

ABSTRACT:
Liposome dispersions are prepared from (a) a synthetic phospholipid of the cephaline type in which the amino group is monoacylated with a dicarboxylic acid; (b) a synthetic phospholipid of the cephaline type; and (c) one or more compounds having pharmacological activity. The mixture optionally can contain phospholipids of natural sources and a pharmaceutical carrier solution buffered to pH 7.0 to 7.8.

REFERENCES:
patent: 4515736 (1985-05-01), Deamer
patent: 4622219 (1986-11-01), Haynes
M. B. Yatvin et al., Science, 210, pp. 1253-1255 (1980).
Harma Ellens et al., Biochemistry 1984, 23, 1532-1538.

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