Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2002-12-18
2009-02-03
Landsman, Robert (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000, C530S308000
Reexamination Certificate
active
07485620
ABSTRACT:
The present invention relates to compositions containing unacylated ghrelin and derivatives thereof and their uses in the control of glycemia in ageing patients, GH deficient patients, diabetic patients and obese patients.
REFERENCES:
patent: 2470235 (2003-06-01), None
patent: 2471879 (2003-11-01), None
patent: 2543507 (2005-05-01), None
patent: WO-0156592 (2001-08-01), None
patent: WO 01/87335 (2001-11-01), None
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Granata, et al., Acylated and Unacylated Ghrelin Promote Proliferaion and Inhibit Apoptosis of Pancreatic beta Cells and Human Islets: Involvement of 3′, 5′—Cyclic Adenosine Monophosphate/Protein Kinase A, Extracellular Signal-Regulated kinase 1/2, and Phosphatidyl Inositol 3-Kinase/Akt Signaling, Endocrinology, vol. 148, No. 2, pp. 512-529, 2007.
Granata, et al., Acylated and unacylate ghrelin proliferation and inhibit serum stravation- and cytokine-induced apoptosis of pancreatic beta cells through cAMP/PKA, ERK 1/2 and P13K/Akt, Abstract and poster presented at Meeting of the Endocrine Society, Boston, from Jun. 24, 2006.
Prodam, et al., Unacylated Ghrelin (UAG) Enhances the Early Insulin Response to Meal, Improves Glucose Metabolism and Decrease Free Faty Acids Levels in Health Volumteers, Abstract and poster presented at European Congress of Endocrinology, Budapest, from Apr. 28, 2007 to May 2, 2007.
Ghigo Ezio
Van Der Lely Aart Jan
Alizé Pharma SAS
Chandra Gyan
Darby & Darby P.C.
Landsman Robert
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