Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-07
1997-12-09
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 13, 530324, 530326, A61K 3818, C07K 14475
Patent
active
056960808
ABSTRACT:
Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.
REFERENCES:
patent: 5470582 (1995-11-01), Supersaxo et al.
Aderka, D. et al., IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production . . . Jour. of Immunol. 143(11):3517-3523 (1989).
Banks, W., et al. Permeability of the blood-brain barrier to peptides: an approach . . . Peptides 13:1289-1294 (1992).
Barde, Y.A. Trophic factors and neuronal survival. Neuron 1:1525-1534 (1989).
Baringe, M. Neurotrophic factors enter the clinic. Science 264:772-774 (1994).
Bazan, J. Neuropoietic cytokines in the hematopoietic fold. Neuron 7:197-208, (1991).
Bradova, V. et al. Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs. Human Genetics 92:143-152 (1993).
Dewji, N. et al., Nucleotide sequence of cloned cDNA for human sphingolipid activator . . . Proc. Natl. Acad. Sci. USA, 84:8652-8656 (1987).
Dewji, N. et al., Molecular cloning of the sphingolipid activator protein . . . Biochem. and Biophys. Res. Commun. 134(2):989-994 (1986).
Fonnum, A rapid radiochemical method for the determination of choline acetyltransferase. Jour. of Neurochemistry 24:407-409 (1975).
Francis, M. et al., Immunological properties of hepatitis B core antigen fusion proteins. Proc. Natl. Acad. Sci. 87:2545-2549 (1990).
Furst, W. et al., The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein. Eur. J. Biochem. 192:709-714 (1990).
Gurney, M. et al., Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor. Jour. of Neuroscience 12(8):3241-3247 (1992).
Hefti, F. et al., Function of neurotrophic factors in the adult and aging brain . . . Neurobiology of Aging 10:515-533 (1989).
Henderson, C. et al., Neurotrophic factors in development and plasticity of spinal neurons. Restorative Neurology and Neuroscience 5:15-28 (1993).
Hiraiwa, M. et al., Binding and transport of gangliosides by prosaposin. Proc. Natl. Acad. Sci. USA, 89:11254-11258 (1992).
Hiraiwa, M. et al., Isolation, characterization, and proteolysis of human prosaposin . . . Arch. Biochem. Biophys. 304(1)110-116 (1993).
Hofer, M. et al., Brain-derived neurotrophic factor prevents neuronal death in vivo. Nature 331:261-262 (1988).
Ip, N. et al., The neurotrophins and CNTP: specificity of action toward PNS and CNS neurons,. J. Physiol., 85:123-130 (1991).
Kishimoto, Y. et al., Saposins: structure, function, distribution, and , molecular genetics. Jour. of Lipid Research, 3:1255-1268 (1992).
Kleinschmidt, T. et al. Complete amino-acid sequence and carbohydrate content of the naturally occurring glucosylceramide activator protein . . . Biological Chemistry Hoppe-Seyler 368(12):1573-1578 (1987).
Kondoh, K. et al. Distribution of prosaposin-like immunoreactivity in rat brain. Jour. of Comparative Neurology 334:590-602 (1993).
Kondoh, K. et al. Isolation and characterization of prosaposin from human milk. Biochem. and Biophys. Res. Commun. 181(1):286-292 (1991).
Krystal, G. A simple microassay for erythropoietin based on 3H-thymidine incorporation . . . Exp. Hematol. 11(7)649-660 (1983).
Kwon, Y. et al., Systemic injections of ciliary neurotrophic factor induce sprouting by adult motor neurons. Neuroreport 5:789-792 (1994).
Lamontagne, S. et al. Modulation of human saposin B sphingolipid-binding specificity by alternative splicing Jour. of Biol. Chem. 269:20528-20532 (1994).
Lin, L. et al., Purification, cloning, and expression of ciliary neurotrophic factor (CNTF). Science 246:1023-1025, (1989).
Lindsay, R. et al., The neurotrophin family of NGF-related neurotrophic factors. Restorative Neurology and Neuroscience 2:211-220 (1991).
Maisonpierre, P. et al., Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science, 247:1446-1451 (1990).
Morimoto, S. et al., Distribution of saposin proteins (sphingolipid . . . ) . Proc. Natl. Acad. Sci. USA, 87:3493-3497 (1990).
Morimoto, S. et al., Saposin A: Second cerebrosidase activator protein. Proc. Natl. Acad. Sci. 86:3389-3393 (1989).
Morimoto, S. et al., Saposin D: A sphingomyelinase activator. Biochemical and Biophysical Research Communications 156(1):403-410 (1988).
O'Brien, J. et al., Identification of prosaposin as a neurotrophic factor. Proc. Natl. Acad. Sci. 91(20):9593-9596 (1994).
O'Brien, J. et al., Isolation and characterization of prosaposin . . . FASEB Jour. 6(4):A969 (1992).
O'Brien, J. et al., Saposin proteins: structure, function, and role in human lysosomal . . . FASEB Jour. 5:301-308 (1991).
O'Brien, J. et al., Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) . . . Science 241:1098-1101 (1988).
Priestle, J. P. et al., Crystallographic refinement of interleukin . . . Proc. Natl. Acad. Sci. 86:9667-9671 (1989).
Purves, D. et al., Trophic regulation of nerve cell morphology and innervation . . . Nature, 336:123-128 (1988).
Rich, K. et al., Nerve growth factor protects adult sensory neurons from cell death . . . Jour. of Neurocytology 16:261-268 (1987).
Rorman, E. et al., Structure and evolution of the human prosaposin chromosomal gene. Genomics 12(2):312-318 (1992).
Sano, A. et al., Protection by prosaposin against ischemia-induced learining disability and neuronal loss. Biochem. and Biophys. Res. Commun. 204(2):994-1000 (1994).
Sano, A. et al., Saposin-C from bovine spleen; complete amino acid sequence and relation between the structure and its biological activity. Biochim. et Biophys. Acta 1120(1):75-80 (1991).
Satomi, D. Developmental changes of glutamate decarboxylase and 2', 3'-cyclic nucleotide . . . Zoological Science 9:127-132 (1992).
Soeda, S. et al., Binding of cerebrosides and sulfatides to saposins A-D*. Jour. of Biol. Chem. 268(25):18519-18523 (1993).
Sprang, S. et al., Cytokine structural taxonomy and mechanisms of receptor engagement. Current Opinion in Structural Biology, 3:815-827 (1993).
Triguero. D. et al., Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J. of Neurochem., 54(6)1882-1888 (1990).
Nakano et al. J. Biochem 105 (1989) 152-154.
Remington's Pharmaceutical Sciences, 18th ed., 1990, ed. A.R. Gennaro, Easton, PA, pp. 1552-1553, 1878-1880.
Kishimoto Yasuo
O'Brien John S.
Hayes Robert C.
Hutzell Paula K.
Myelos Neurosciences Corporation
LandOfFree
Pharmaceutical compositions comprising neurotrophic peptides der does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions comprising neurotrophic peptides der, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions comprising neurotrophic peptides der will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1607664