Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1992-12-17
1994-03-22
Friedman, S. J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514784, 514788, 514946, A61K 3166
Patent
active
052964752
ABSTRACT:
The invention relates to pharmaceutical compositions for peroral administration comprising (a) pharmaceutically useful methanediphosphonic acid derivatives, e.g. those of formula I ##STR1## wherein R.sub.1 and R.sub.2 are as defined in the specification, or pharmaceutically acceptable salts thereof, (b) specific macrocyclic polyethers and optionally (c) pharmaceutically acceptable adjuvants. The pharmaceutical compositions are prepared in a manner known per se. A method of treating hypercalcemia and osteolytic bone metastases with these compositions is also disclosed herein.
REFERENCES:
patent: 3962432 (1976-06-01), Schmidt-Dunker
patent: 4134969 (1979-01-01), Schmidt-Dunker
patent: 4269828 (1981-05-01), Flora et al.
patent: 4275059 (1981-06-01), Flora et al.
patent: 4980171 (1990-12-01), Fels et al.
patent: 5096717 (1992-03-01), Wirth et al.
Derwent Abstract 89-249746/35 Corresponding to PCT 89/7453, 1989.
Dutton et al. "Synthesis and Metal Ion Complexation Behavior of Polycarboxylate 18-Crown-6 Ethers Derived from Tartaric Acid", Can. J. Chem. 66, pp. 1097-1108 (1988).
Hrigiga et al. "pH Regulation of Divalent/Monovalent Ca/K Cation Transport Selectivity by a Macrocyclic Carrier Molecule", Proc. Natl. Acad. Sci. USA, 80, pp. 6426-6428 (1983).
European Patent Office Search Report, May 18, 1993 for EP 92 81 0990.
Helvetica Chimica Acta, 65, pp. 1853-1867, 1982.
Helvetica Chimica Acta, 63, pp. 2096-2111, 1980.
Behr et al. 220. "Molecular Receptors. Functionalized and Chiral Macrocyclic Polyethers Derived from Tartaric Acid".
Journal of Chromatography, 489, pp. 446-451, 1989. Flesch et al.
Journal of Chromatography, 568, pp. 261-266, 1991. Flesch et al.
Flesch Gerard
Lehn Jean-Marie
Ciba-Geigy Corporation
Fishman Irving M.
Friedman S. J.
Ikeler Barbara J.
Jarvis William
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