Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2003-03-14
2008-12-09
Kosar, Andrew D (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07462596
ABSTRACT:
The present invention relates to pharmaceutical compositions comprising MBL and/or MBL variants. In particular the invention relates to pharmaceutical compositions comprising at least 200 μg/ml protein containing material, wherein mannan binding lectin (MBL) and/or MBL variants constitutes at least 35% (w/w) of the total protein; or to compositions comprising at least 400 μg/ml mannan binding lectin (MBL) and/or MBL variants. In addition the invention relates to pharmaceutical compositions comprising MBL and/or MBL variants and divalent cations. The invention also describes methods of preparing said compositions.The pharmaceutical compositions according to the invention may for example be used in methods of treatment of a number of different clinical conditions including infections. Uses of the compositions for preparation of medicaments for treatment of a clinical condition are also described.
REFERENCES:
patent: 6297024 (2001-10-01), Hugli et al.
patent: 6429192 (2002-08-01), Laursen
patent: 6562784 (2003-05-01), Thiel et al.
patent: 2003/0198998 (2003-10-01), Uttenthal
patent: WO 99/64453 (1999-12-01), None
Rudinger, J. “Characteristics of the amino acids as components of a peptide hormone sequence” in Peptide Hormones, J. A. Parsons, Editor. Biological Council The Co-ordinating Committee for Symposia on Drug Action. Jun. 1976, pp. A0 and 1-7.
Weis et al. Physical Characterization and Crystallization of the Carbohydrate-recognition Domain of a Mannose-binding Protein from Rat. J Biol Chem 1991, vol. 266, No. 31, pp. 20678-20686.
Vorup-Jensen et al. Distinct Pathways of Mannan-Binding Lectin (MBL)- and C1-Complex Autoactivation Revealed by Reconstitution of MBL with Recombinant MBL-Associated Serine Protease-2. J Immunol 2000. vol. 165, pp. 2093-2100.
Tan et al. Improvements on the purification of mannan-binding lectin and demostration of its Ca2+-independent association with a C1s-like serine protease. Biochem J. 1996. vol. 319, pp. 329-332.
Kilpatrick. Mannan-binding lectin and its role in innate immunity. Transfusion Medicine. 2002. vol. 12, pp. 335-351.
SIGMA. Designing Custom Peptides. http://www.sigma-genosys.com/peptide—design.asp (Accessed Dec. 16, 2004) 2 pages.
HJC Berendsen. A Glimpse of the Holy Grail? Science (1998) vol. 282., pp. 642-643.
D Voet and JG Voet. Biochemistry, 2nd edition, (1995) pp. 235-241.
DE Smilek et al. A single amino acid change in a myelin basic peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA (1991) vol. 88, pp. 9633-9637.
Dictionary.com. Entries for “stable” http://dictionary.reference.com/search?q=stable (Accessed Jul. 20, 2005) 1 page.
Akers et al. Sterile Formulation (Chapter 14) in Vogel et al, Fermentation and Biochemical Engineering Handbook—Principles, Process Design, and Equipment (2nd Edition). 1997, pp. 616-634 and 2 cover pages.
Laursen, I. MBL production from human plasma. Mar. 20, 2003. Royal College of Physicians of Edinburgh. Therapeutic Applications oof Mannan-Binding Lectin. S4 and pp. 1-2.
Laursen, Inga, “Mannen-binding lectin, a new plasma product: production process and clinical application”,Plasma Product Biotechnology(PPB)Meeting, May 14-17, 2001, pp. 15-17.
Laursen, I, “Mannan-binding lectin (MBL) production from human plasma”,Biochemical Society Transactions, vol. 31, part 4, pp. 758-762, 2003.
Kongerslev Leif
{hacek over (L)}arsen Jesper Lund
Cooper Iver P.
Cordero Garcia Marcela M
Kosar Andrew D
Natimmune A/S
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