Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-07-01
2008-07-01
Borin, Michael (Department: 1631)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S324000, C514S021800
Reexamination Certificate
active
10192806
ABSTRACT:
The present invention relates to pharmaceutical compositions comprising therapeutically effective amounts of fragments or homologs of troponin C, I or T subunits for the treatment of diseases or disorders involving abnormal angiogenesis.
REFERENCES:
patent: 5583200 (1996-12-01), Larue et al.
patent: 5837680 (1998-11-01), Moses et al.
patent: 6025331 (2000-02-01), Moses et al.
patent: 2 275774 (1994-09-01), None
patent: WO97 30085 (1997-08-01), None
Altschul et al., 1990, “Basic local alignment search tool”, J Mol Biol 215:403-410.
Altschul et al., 1997 “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs”, Nuc Acids Res 25:3389-3402.
Auerbach et al., 1985, “Expression of organ-specific antigens on capillary endothelial cells”, Microvasc Res 29:401-411.
Baldwin, Jr., et al., 1985, “Structure, evolution and regulation of a fast skeletal trooponin I gene”, Proc. Natl. Acad. Sci. USA, 82:8080-8084.
Blood and Zetter, 1990, “Tumor interactions with the vasculature: angiogenesis and tumor metastasis”, Biochem Biophys Acta 1032:89-118.
Boyden et al., 1962, “The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes”, J. Exp. Med. 115: 453-466.
Brekke and Greaser, 1976, “Separation and characterization of the troponin components from bovine cardiac muscle”, J Biol Chem 251:886-871.
Chen et al., 1988, FEBS Lett. 228:22-26.
Chen et al., 1995, “A strategy to discover circulating angiogenesis inhibitors generated by human tumors”, Cancer Res 55:4230-4233.
D'Amore, 1986, “Growth factors, angiogenesis and metastasis”, Prog Clin Bio Res 221:269-283.
D'Amore and Smith, 1993, “Growth factor effects on cells of the vascular wall: a survey”, Growth Factors 8:61-75.
Ebashi et al., 1968, “Troponin: Preparation and physiological function”, J Biochem 64:465.
Falk et al., 1980, “A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration”, J Immunol Methods 33:239-247.
Folkman, 1985, “Tumor angiogenesis”, inAdvances in Cancer Research, vol. 43, Klein and Weinhouse (eds.), Academic Press, NY, pp. 175-203.
Folkman et al., 1983, “Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone”, Science 221:719-725.
Folkman and Klagsbrun, 1987, “Angiogenic factors”, Scieice 235:442-447.
Folkman et al., 1989, “Control of angiogenesis with synthetic heparin substitutes”, Science 243:1490-1493.
Folkman, 1995, “Clinical applications of research on angiogenesis”, New Eng J Med 333:1757-1763.
Gahlmann et al., 1988, J. Mol. Biol. 201:379-391.
Gahlmann and Kedes, 1990, “Cloning, structural analysis, and expression of the human fast twitch skkeletal muscle troponin C gene”, J Biol Chem 265:12520-12528.
Garabarek and Drabikowski, 1981, “Proteolytic fragments of troponin C: Interactions with the other troponin subunits and biological activity”, J Biol Chem 256:13121-13127.
Gartner and Henkind, 1978, “Neovascularization of the iris (Rubeosis Iridis)”, Surv. Ophthalmol. 22: 291-312.
Gerson, S.L., 1999, Nature Med. 5: 262-264.
Glaser and D'Amore, 1980, “Adult tissues contain chemo-attractants for vascular endothelial cells”, Nature 288:483-484.
Greaser and Gergely, 1971, “Reconstitution of troponin activity from three proteins components”, J Biol Chem 246:4226-4233.
Greaser and Gergely, 1973, “Purification and properties of the components from tropinin”, J Biol Chem 248:2125-2133.
Hartshorne and Mueller, 1968, “Fractionation of troponin into two distinct proteins”, Biochem Biophys Res Comm 31:647-653.
Haudenschild et al., 1976, “Human vascular endothelial cells in culture. Lack of response to serum growth factors”, Exp. Cell. Res. 98: 175-183.
Hartshorne and Mueller, 1969, “The preparation of tropomyosin and troponin frm natural actomyosin”, Biochim Biophys Acta 175:301-319.
Higgins et al., 1996, “Using CLUSTAL for multiple sequence alignments”, Methods Enzymol 266:383-402.
Hodges et al., 1988, “computer simulation of high-performance liquid chromatographic separations of peptide and protein digest for development of size-exclusion, ion-exchange and reversed-phase chromatographic methods”, J Chromatogr. 458:147-167.
Howard et al., 1989, “Intracerebral drug delivery in rats with lesion-induced memory deficits”, J Neurogurg 71:105-112.
Jha et al., 1996, “Photo-cross-linking of rabbit skeletal troponin I deletion mutants with troponin C and its thoil mutants: The inhibitory region enhances binding of troponin I fragments to troponin C”, Biochem 35:11026-11035.
Klagsbrun et al., 1977, “The stimulation of DNA synthesis and cell division in chondrocytes and 3T3 cells by a growth factor isolated from cartilage”, Exp Cell Res 105:99-108.
Klagsbrum et al., 1991, “Regulators of angiogenesis”, Annu Rev Physiol 53:217-239.
Kohn et al., 1997, Clin. Exp. Immunol. 107: 54-57.
Langer and Folkman, 1976, “Polymers for the sustained release of proteins and other macromolecules”, Nature 263:797-800.
Langer et al., 1976, “Isolation of a cartilage factor that inhibits tumor neovascularization”, Science 193:70-72.
Langer and Peppas, 1983, “Chemical and physical structure of polymers as carriers for controlled release of bioactive agents: a review”, J Macromol Sci Rev Macromol Chem Phys 23:61-126.
Langer, 1990, “New methods of drug delivery”, Science 249:1527-1533.
Levy et al., 1985, “Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate”, Science 228:190-192.
Lutty et al., 1983, “Vitreous: An inhibitor of retinal extract-induced neovascularization”, Invest Ophthamol Vis Sci 24:52-56.
Mant et al., “Separation of peptides by strong cation-exchange high-performance liquid chromatography”, J Chromatogr., 327: 147-155.
Morris and Lehrer, 1984, “Troponin-tropomyosin interactions. Fluorescence studies of the binding of troponin, troponin T and chimotryptic troponin T fragments to specifically labeled tropomyosin”, Biochem 23:2214-2220.
Moses et al., 1990, “Identification of an inhibitor of neovascularization from cartilage”, Science 248:1408-1410.
Moses et al., 1992, “Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes”, J Cell Biol 119:475-482
Moses and Langer, 1991, “Inhibitors of angiogenesis”, Biotechnology 9:630-634.
Moses et al., 1995, “The role of growth factors in vascular cell development and differentiation”, Intl Rev Cytology, 161:1-48.
Moses et al., 1999, Troponin I is present in human cartilage and inhibits angiogenesis, Proc Natl Acad Sci USA 96:2645-2650.
Nash et al., 1996, “Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily” Curr Biol 6:968-980.
Nikovits et al., 1986, “The chicken fast skeletal troponin I gene: exon organization and sequence”, Nucleic Acid. Res., 14:3377-3390.
O'Reilly et al., 1996, “Angiostatin induces and sustains dormancy of human primary tumors in mice”, Nat Med 2:689-692.
Patz et al., 1982, “Clinical and experimental studies on retinal neovascularization”, Am J Ophthamol 94:715-743.
Pearson and Lipman, 1988, “Improved tools for biological sequence comparison” Proc Natl Acad Sci USA 85:2444-2448.
Polverini et al., 1991, “Assay and purification of naturally occurring inhibitor of angiogenesis”, Meth Enzymol 198:440-450.
Quaggio et al., 1993, Protein Science 2: 1053-1056.
Rastinejad et al., 1989, “Regulation of the activi
Moses Marsha A
Wiederschain Dmitri G.
Borin Michael
Children's Medical Center Corporation
Nixon & Peabody LLP
LandOfFree
Pharmaceutical compositions comprising fragments and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions comprising fragments and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions comprising fragments and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3957573