Pharmaceutical compositions comprising attenuated HIV-1...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C435S236000

Reexamination Certificate

active

07491400

ABSTRACT:
A therapeutic suspension for the treatment of human immunodeficiency virus type I (HIV-1) infection in humans using isolated and purified HIV-1 nef-deficient viral particles having a nef-deletion between the endonuclease cleavage sites Nco I and Xho I.

REFERENCES:
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Mooji, P., et al., 2002, “Rational development of prophylactic HIV vaccines based on structural and regulatory proteins”, Vaccine 20:304-321.
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Gallo, R. C., 2005, “The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years”, Lancet 366:1894-1898.
Betts, M. R., et al., 2005, “Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection”, Proc. Natl. Acad. Sci. USA 102(12):4512-4517.
Johnson, R. P., 1999, Live attenuated AIDS vaccines: Hazards and hopes, Nat. Med. 5(2):154-155.
Baba, T. W., et al., 1999, Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques, Nat. Med. 5(2): 194-203.
Hofmann-Lehmann, R. et al., 2003, Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation, AIDS 17:157-166.

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