Pharmaceutical compositions based on NK2 antagonists for...

Details Pharmaceutical compositions based on NK2 antagonists for... Pharmaceutical compositions based on NK2 antagonists for...

2005-10-26

2010-06-01

Ha, Julie (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S210200, C514S212010, C514S317000, C514S320000, C514S326000

Reexamination Certificate

active

07727955

ABSTRACT:
Pharmaceutical compositions containing NK2 antagonists are described, useful for the treatment of infantile colics.

REFERENCES:
patent: WO 9628467 (1996-09-01), None
patent: WO 0129066 (2001-04-01), None
patent: WO 03037916 (2003-05-01), None
patent: WO 2004037266 (2004-05-01), None
Colic from Merck Manual, pp. 1-2. Accessed Jun. 24, 2009.
Colic from Mylicon.com, http://www.mylicon.com/why/index.jhtml?id=mylicon/cry/colic.inc, pp. 1-2. Accessed Jun. 25, 2009.
All about Infant Gas from Mylicon.com, http://www.mylicon.com/infantgas/index.jhtml, pp. 1-2. Accessed Jun. 25, 2009.
Colic from Bupa Health, http://hcd2.bupa.co.uk/fact—sheets/Mosby—factsheets/infant-colic.html, pp. 1-6. Accessed Jun. 24, 2009.
Magnan et al., “Effects of Intrathecal NK-1 and NK-2 Antagonists on Xylene-induced Cystitis in Rat,” Neuropeptides: Function and Pharmacology, vol. 24, p. 199-200 (1993).
Camilleri, “Management of the Irritable Bowel Syndrome,” Gastroenterology 2001; 120:652-668.
Mayer et al., “Basic and Clinical Aspects of Visceral Hyperalgesia,” Gastroenterology 1994; 107:271-293.
Anton et al., “Chronic low-level administration of diquat increases the nociceptive response to gastric distention in rats . . . ,” Pain 92 (2001) 219-227.
McLean et al., “Effects of nematode infection on sensitivity to intestinal distension . . . ,” European Journal of Pharmacology 337 (1997) 279-282.
Toulouse et al., “Role of tachykinin NK2 receptors in normal and altered rectal sensitivty in rats,” British Journal of Pharmacology (2000) 129, 193-199.
Lippi et al., “Pharmacokinetics of the Bicyclic Peptide Tachykinin NK2 Receptor Antagonist Men 11420 . . . ,” Drug Metabolism and Disposition, vol. 26 No. 11 1077-1081, 1998.
Williams et al., “Dicyclomine: worrying symptoms associated with its use in some small babies,” British Medical Journal, vol. 288, Mar. 24, 1984, 901.
Wade et al., “Infantile colic,” British Medical Journal, Clinical review, vol. 323, Aug. 25, 2001, 437-440.
Metcalf et al., “Simethicone in the Treatment of Infant Colic: A Randomized, Placebo-Controlled, Multicenter Trial,” Pediatrics vol. 94 No. 1 Jul. 1994, 29-34.
Danielsson et al., “Treatment of Infantile Colic with Surface Active Substance (Simethicone),” Acta Paediatr Scand 74: 446-450, 1985.
Giuliani et al., “Effect of a tachykinin NK2receptor antagonist, nepadutant, on cardiovascular and gastrointestinal function in rats and dogs,” European Journal of Pharmacology 415 (2001) 61-71.

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