Pharmaceutical compositions as inhibitors of dipeptidyl...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S146000, C548S200000, C548S517000, C548S518000, C514S408000, C514S422000, C514S423000

Reexamination Certificate

active

07348346

ABSTRACT:
The present invention relates to compounds of formula (I),which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.

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Sakashaita, H., et al.1-((S)-c-Substituted prolyl)-(S)-2-cyanopyrrolidine as a novel series of highly potent DPP-IV inhibitorsBioorg. Med. Chem. Lett. 15: 2441-2445 (2005).
Sakashaita, H., et al. [(S)-c-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitorsBioorg. Med. Chem. Lett. 14: 3662-3671 (2006).
Tsai, et al.Substituted pyrrolidine-2,4-icarboxylic acid amides as potent dipeptidyl peptidase IV inhibitorsBioorg. Med. Chem. Lett. 16: 3268-3272 (2006).
Guohua, et al.,Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitorsBioorg. Med. Chem. Lett . 15: 3992-3995 (2005).

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