Pharmaceutical compositions as inhibitors of dipeptidyl...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S343000, C514S422000, C514S423000, C546S208000, C546S276400, C548S538000, C548S518000

Reexamination Certificate

active

10788993

ABSTRACT:
The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.

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Coutts, Simon J., Structure-Activity Relationships of Boronic Acid Inhibitors of Dipeptidyl Peptidase IV. 1. Variation of the P2Position of Xaa-boroPro Dipeptides
Ahren, B., “Inhibition of Dipeptidyl Peptidase IV Improves Metabolic Control over a 4-Week Study Period in Type 2 Diabetes”, Diabetes Care, vol. 25, No. 5, May 2002, pp. 869-875.
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Villhauer, Edwin B., “1-3-Hydroxy-1-adamantyl) amino acetyl-2-cyano-(S)-pyrrolidine: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties,” J. Med. Chem. 2003, vol. 46, pp. 2774-2789.
Hughes, T.E., “1-2-3 Cyanopyridin-2-yl) amino ethyl amino acetyl-2-cyano-(S) pyrrolidine), a Slow Binding Inhibitor of Dipeptidyl Peptidase IV”, Biochemistry 1999, vol. 38, pp. 11597-11603.

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