Pharmaceutical compositions as inhibitors of dipeptidyl...

Details Pharmaceutical compositions as inhibitors of dipeptidyl... Pharmaceutical compositions as inhibitors of dipeptidyl...

2007-04-17

2007-04-17

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S268100, C548S518000

Reexamination Certificate

active

10935053

ABSTRACT:
The present invention relates to compounds of formula (I),which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, β-cell failure, obesity, satiety disorders, atherosclerosis, and various immunomodulatory diseases.

REFERENCES:
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patent: 6110949 (2000-08-01), Villhauer
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Villhauer et al., “1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties,” Journal of Medicinal Chemistry 46(13):2774-2789 (2003).
Ashworth et al., “2-cyanopyrrolidides as potent, stable inhibitors of dipeptidyl peptidase IV,” Bioorganic & Medicinal Chemistry Letters 6(10):1163-1166 (1996).

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