Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-12-09
1996-11-19
Kight, III, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514781, 514866, 514867, 514884, 514824, 426658, 426804, 424439, 424441, 424461, 424479, 424480, 424493, 424494, A01N 4304, A01N 2500, A61K 4700
Patent
active
055763065
ABSTRACT:
Water-soluble, high-viscosity grade cellulose ether compositions are useful for the reduction of serum lipid levels, particularly total serum cholesterol, serum triglycerides, and low-density lipoprotein (LDL) levels and/or attenuate the postprandial rise of blood glucose levels in animals. The pharmaceutical uses of compositions for reducing cholesterol levels additionally include the treatment of diabetes and/or hypercholesterolemia, with avoidance of many of the undesirable side effects associated with other forms of treatment. The composition may be in the form of a prehydrated ingestible composition, such as a gelatin, or a comestible, such as a cookie. In addition, the compositions of the present invention are palatable to the patient, thereby enhancing patient compliance with the regimen.
REFERENCES:
patent: 2701782 (1955-02-01), Culter
patent: 2802741 (1957-08-01), Weaver
patent: 2883327 (1959-04-01), Dale
patent: 3308020 (1967-03-01), Wolf et al.
patent: 3342805 (1967-09-01), Callihan
patent: 3383281 (1968-05-01), Wolf et al.
patent: 3388082 (1968-06-01), Rodgers, Jr. et al.
patent: 3499960 (1970-03-01), Macek et al.
patent: 3627872 (1971-12-01), Parkinson
patent: 3709876 (1973-01-01), Glomski et al.
patent: 3721735 (1973-03-01), Thiffault
patent: 4109018 (1978-08-01), Thompson
patent: 4251519 (1981-02-01), Robbins et al.
patent: 4265879 (1981-05-01), Fields et al.
patent: 4284649 (1981-08-01), Wiczer
patent: 4410693 (1983-10-01), Gibson et al.
patent: 4451490 (1984-05-01), Silverman et al.
patent: 4461782 (1984-07-01), Robbins et al.
patent: 4477657 (1984-10-01), Strange et al.
patent: 4614545 (1986-09-01), Hess
patent: 4626287 (1986-12-01), Shah et al.
patent: 4704285 (1987-11-01), Alderman
patent: 4732917 (1988-03-01), Shah et al.
patent: 4789664 (1988-12-01), Seligson et al.
patent: 4820813 (1989-04-01), Schultz
patent: 4824675 (1989-04-01), Wong et al.
patent: 4883788 (1989-11-01), Day et al.
patent: 4892747 (1990-01-01), Ohta
patent: 4915954 (1990-04-01), Ayer et al.
patent: 4919938 (1990-04-01), Lovegrove et al.
patent: 4923981 (1990-05-01), Weibel et al.
patent: 4950140 (1990-08-01), Pflaumer et al.
patent: 4996063 (1991-02-01), Inglett
Anderson, et al., Hypocholesterolemic Effects of Oat Bran or Bean Intake Hypercholesterolemic Men, Am. J. Clin. Nutr., vol. 40, pp. 1146-1155 (1984).
Anderson, et al., Cholesterol-Lowering Effects of Psyllium Hydrophilic Mucilloid for Hypercholesterolemic Men, Arch. Intern. Med., vol. 148, pp. 292-296 (1988).
Anderson, et al., Oat-Bran Cereal Lowers Serum Total and LDL Cholesterol in Hypercholesterolemic Men, Am. J. Clin. Nutr., vol. 52, pp. 495- (1990).
Arutyunova, et al., Vopr. Pitan., 1989, (6), 47-5 (Russ.) Chemical Abstracts 112(15)):138045F Apr. 9, 1990.
Benko, et al., A Study of Vascular Lesions Induced By Cholesterol Feeding and Methycellulose Administration in Rabbits, Cor. Vasa. vol. 12, No. 1, pp. 65-74 (1970).
Benko, et al., Chem. Abstracts, vol. 72, No. 21, 25 May 1970 (Abstract No. 109611N on p. 236).
Bosello, et al., Effects of Guar Gum on Plasma Lipoproteins and Apolipoproteins C-II and C-III in Patients Affected by Familial Combined Hyperlipoproteinemia, Am. J. Clin. Nutr., vol. 40, pp. 1165-1174 (1984).
Chen, et al., Proc. Soc. Exp. Biol. Med., vol. 162, No. 2, pp. 310-313 (1979); Chemical Abstract No. 92:21120d, vol. 92, p. 570 (1980).
Costa, et al., Effects of Dietary Cellulose, Psyllium Husk, and Cholesterol Level on Fecal and Colonic Microbial Metabolism in Monkeys, Am. Inst. Nutr., pp. 986-992 (1989).
Fuse, et al., Effects of Pectin on Fatty Acid and Glucose Absorption and on Thickness of Unstirred Water Layer in Rat and Human Intestine, Dig. Dis. Sci., vol. 34, No. 7, pp. 1109-1116 (1989).
Gold and Davidson, Oat Bran as a Cholesterol-Reducing Dietary Adjunct, West J. Med., vol. 148, pp. 299-302 (1988).
Hillman, et al., The Effects of The Fiber Components Pectin, Cellulose, and Lignin on Serum Cholesterol Levels, Am. J. Clin. Nutr., vol. 42, pp. 207-213 (1985).
Holt, et al., Effect of Gel Fibre On Gastric Emptying And Absorption of Glucose and Paracetamol. The Lancet, pp. 636-639 (Mar. 24, 1979).
Jenkins, et al., British Medical J., vol. 1, No. 6124, pp. 1392-1394 (1978).
Lalor, et al., Placebo-Controlled Trial of the Effects of Guar Gum and Metformin on Fasting Blood Glucose and Serum Lipids in Obese, Type 2 Diabetic Patients, Diabetic Med., vol. 7, pp. 242-245 (1990).
Lee, et al., Cholesterol-Lowering by Hydroxypropyl Methylcellulose and Guar Gum with Different Viscosities, Fed. Am. Soc. Exp. Biol. J., vol. 5, No. 5, pp. 21-23, Apr. 1991.
Lo, et al., Soy Cotyledon Fiber Products Reduce Plasma Lipids, Antherosclerosis, vol. 82, pp. 59-67 (1990).
McIvor, et al., Flattening Postprandial Blood Glucose Response With Guar Gum: Acute Effects, Diabetes Care, vol. 8, No. 3, pp. 274-278 (May-Jun. 1985).
Morgan, et al., The Effect of Soluble- and Insoluble-fibre Supplementation on Post-Prandial Glucose Tolerance, Insulin and Gastric Inhibitory Polypeptide Secretion in Healthy Subjects, Br. J. Nutr., vol. 64, pp. 103-110 (1990).
Munoz, et al., American Journal of Clincal Nutrition, vol. 32, pp. 580-592 (Mar. 1979).
Nightingale, "Lipid Binding From Aqueous Solution By Lipid Conjugated Hydroxypropylmethylcellulose," Dissertation, 1988.
Reppas, et al., Effect of Hydroxyproplymethylcellulose on Gastrointestinal Transit and Luminal Viscosity in Dogs, Gastroenterology, vol. 100, No. 5, pp. 1217-1223 (1991).
Requejo, et al., Effects of .alpha.-Glucosidase Inhibition and Viscous Fibre on Diabetic Control and Postprandial Gut Hormone Responses, Diabetic Med., vol. 7, pp. 515-520 (1990).
Schwartz, et al., Sustained Pectin Ingestion: Effect on Gastric Emptying and Glucose Tolerance in Non-Insulin Dependent Diabetic Patients, Am. J. Clin. Nutr., vol. 48, pp. 1413-1417 (1988).
Seidner, et al., Esophageal Obstruction After Ingestion of a Fiber-Containing Diet Pill, Gastroenterology, vol. 99, pp. 1820-822 (1990).
Sirois, et al., Gastric Emptying of Nondigestible Solids in Dogs: a Hydrodynamic Correlation, Amer. J. Physiol., vol. 258, pp. G65-72 (1990).
Stahl, et al., Vergleich de Wirkun von Guar, Weizenkleie und Placebo auf den Kohlenhydrat-und Fettstoffweshel bei Typ II Diabetikern, Schweiz. Med. Wschr., vol. 120, pp. 402-408 (1990).
Superko, et al., Effects of Solid and Liquid Guar Gum on Plasma Cholesterol and Triglyceride Concentrations in Moderate Hypercholesterolemia, Am. J. Cardiol, vol. 62, pp. 51-55 (1988).
Swain, et al., Comparison of the Effects of Oat Bran and Low-Fiber Wheat on Serum Lipoprotein Levels and Blood Pressure, New Eng. J. Med., vol. 322, pp. 147-152 (1990).
Topping, et al., A Viscous Fibre (methylcellulose) Lowers Blood Glucose and Plasma Triacylglycerols And Increases Liver Glycogen Independently of Volatile Acid Production In The Rat, British J. Nutrition, vol. 59, No. 1, pp. 21-30 (1988).
Torsdottir, et al., Dietary Guar Gum Effects on Postprandial Blood Glucose, Insulin, and Hydroxyproline in Humans, J. Nutr., vol. 119, pp. 1925-1931 (1989).
Tsai, et al., Effects of soy Polysaccharide On Postprandial Plasma Glucose, Insulin, Glucagon, Pancreatic Polypeptide, Somatostatin, and Triglyceride in Obese Diabetic Patients, Am J. Clin. Nutr., vol. 45, pp. 596-601 (1987).
Tsuji, et al., Effects of Polysaccharides on Cholesterol Metabolism, VII. Effects of Various Synthetic Polymers on Serum and Liver Cholesterol Levels in Rats, Chemical Abstracts, vol. 89, No. 7, p. 485, Abstract No. 89:58752A, Aug. 14, 1978 (Eiyogaku Zasshi, vol. 35, No. 5, pp. 227-234 (1977)).
Uusitupa, et al., Metabolic and Nutritional Effects of Long-Term Use of Guar Gum in the Treatment of Noninsulin-Dependent Diabetes of Poor Metabolic Control, Am. J. Clin. Nutr., vol. 49, pp. 345-351 (1989).
F-D-C Reports, Jul. 30, 1990 entitled "Procter & Gamble's Metamucil Psyllium Cholesterol-Lowering Claim" pp. T&G-3 and T&G-4.
Biochemistry, Lubert Stryer, 3rd edition, pages *, pp. 559-564.
Martindale The Extra Pharmacopoeia, 28th Ed., pp. 947-963 (1985) "Methylcellulose and Stabilising and Suspending Agents".
Dressman Jennifer B.
Reppas Christos
Sowle Cynthia W.
Tobey Stephen W.
Board of Regents Acting for and on Behalf of the University of M
Dow Chemical Company
Kight III John
Leary Louise N.
LandOfFree
Pharmaceutical compositions and uses of water-soluble, high-visc does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions and uses of water-soluble, high-visc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions and uses of water-soluble, high-visc will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-541108