Pharmaceutical compositions and uses of inorganic pyrophosphates

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514114, 514851, 424601, A61K 3166, A61K 3342

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active

059589078

ABSTRACT:
Pharmaceutical compositions comprising an inorganic pyrophosphate (PPi) in a form that renders the PPi accessible to ABC proteins when administered to a subject in vivo, as well as use of the compositions for treating subjects having a disease or disorder associated with inappropriate or inadequate ABC protein activity (e.g., cystic fibrosis, multi drug resistance, Zellweger's Syndrome) is disclosed.

REFERENCES:
patent: 5407661 (1995-04-01), Simone et al.
patent: 5686114 (1997-11-01), Welsh
Anderson, M.P. and M.J. Welsh (1992) "Regulation by ATP and ADP of CFTR Chloride Channels That Contain Mutant Nucleotide-Binding Domains" Science 257:1701-1704.
Anderson, M.P. et al. (1991) "Nucleoside Triphosphates Are Required to Open the CFTR Chloride Channel" Cell 67:775-784.
Bartels, E.M. et al. (1993) "The myosin molecule--charge response to nucleotide binding" Biochem. Biophys. Acta 1157:63-73.
Baukrowitz, T. et al. (1994) "Coupling of CFTR CI.sup.- Channel Gating to an ATP Hydrolysis Cycle" Neuron 12:473-482.
Berger, H.A. et al. (1993) "Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator CI.sup.- Channel by Specific Protein Kinases and Protein Phosphatases" J. Biol. Chem. 268:2037-2047.
Bhalla, K. et al. (1985) "Isolation and Characterization of an Anthracycline-resistant Human Leukemic Cell Line" Cancer Res. 45:3657-3662.
Blobel, C.P. et al. (1992) "A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion" Nature 356:248-251.
Busche, R. et al. (1989) "Equilibrium, kinetic and photoaffinity labeling studies of daunomycin binding to P-glycoprotein-containing membranes of multidrug-resistant Chinese hamster ovary cells" Eur. J. Biochem. 183:189-197.
Busche, R. et al. (1989) "Preparation and Utility of a Radioiodinated Analogue of Daunomycin in the Study of Multidrug Resistance" Mol. Pharmacol. 35:414-421.
Carson, M.R. et al. (1994) "Phosphate Stimulates CFTR CI.sup.- Channels" Biophys. J. 67(5):1867-1875.
Chen, C.-J. et al. (1986) "Internal Duplication and Homology with Bacterial Transport Proteins in mdr1 (P-Glycoprotein) Gene from Multidrug-Resistant Human Cells" Cell 47:381-389.
Croop, J.M. et al. (1988) "Genetics of Multidrug Resistance" J. Clin. Invest. 81:1303-1309.
Cutting, G.R. et al. (1990) "A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regular protein" Nature 346:366-369.
Dalemans, W. et al. (1991) "Altered chloride ion channel kinetics associated with the F508 cystic fibrosis mutation" Nature 354:526-528.
Dean, M. et al. (1990) "Multiple Mutations in Highly Conserved Residues Are Found in Mildly Affected Cystic Fibrosis" Cell 61:863-870.
Denning, G.M. et al. (1992) "Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive" Nature 358:761-764.
Deverson, E.V. (1990) "MHC class II regions encoding proteins related to the multidrug resistance family of transmembrane transporters" Nature 348:738-740.
Endicott, J.A. and V. Ling (1989) "The Biochemistry of P-Glycoprotein-Mediated Multidrug Resistance" Annu. Rev. Biochem. 58:137-171.
Fleisch, H. et al. (1991) "Biophosphates: Pharmacology and Use in the Treatment of Tumour-Induced Hypercalcaemic and Metastatic Bone Disease" Drugs 42(6):919-944.
Frizzell, R.A. et al. (1986) "Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis" Science 233:558-560.
Goldfischer, S. et al. (1973) "Peroxisomal and Mitochondrial Defects in the Cerebro-Hepato-Renal Syndrome" Science 182:62-64.
Goldstein, L.J. et al. (1989) "Expression of a Multidrug Resistance Gene in Human Cancers" J. Natl. Cancer Inst. 81:116-124.
Gottesman and Pastan (1988) "The Multidrug Transporter, a Double-edged Sword" J. Biol. Chem. 263:12163-12166.
Greene, L.E. and E. Eisenberg (1980) "Dissociation of the Actin-Subfragment 1 Complex by Adenyl-5'-yl Imidodiphosphate, ADP, and PP.sub.i " J. Biol. Chem. 255(2):543-548.
Gregory, R.J. et al. (1990) "Expression and characterization of the cystic fibrosis transmembrane conductance regulator" Nature 347:382-386.
Gros, P. et al. (1986) "Isolation and expression of a complementary DNA that confers multidrug resistance" Nature 323:728-731.
Gros, P. et al. (1986) "Mammalian Multidrug Resistance Gene: Complete cDNA Sequence Indicates Strong Homology to Bacterial Transport Proteins" Cell 47:371-380.
Gunderson, K.L. et al. (1994) "Effects of Pyrophosphate and Nucleotide Analogs Suggest a Role for ATP Hydrolysis in Cystic Fibrosis Transmembrane Regulator Channel Grating" J. Biol. Chem. 269(30):19349-19353.
Hamada, H. and T. Tsuruo (1988) "Purification of the 170- to 180-Kilodalton Membrane Glycoprotein Associated with Multidrug Resistance" J. Biol. Chem. 263:1454-1458.
Hartman, J. et al. (1992) "Recombinant Synthesis, Purification, and Nucleotide Binding Characteristics of the First Nucleotide Binding Domain of the Cystic Fibrosis Gene Product" J. Biol. Chem. 267:6455-6458.
Hwang, T.-C. et al. (1989) "CI.sup.- Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase" Science 244:1351-1353.
Hwang, T.-C. et al. (1994) "Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis" PNAS USA 91:4698-4702.
Hyde, S.C. et al. (1990) "Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport" Nature 346:362-365.
Imanaka, T. et al. (1987) "Translocation of Acyl-CoA Oxidase into Peroxisomes Requires ATP Hydrolysis but Not a Membrane Potential" J. Cell Biol. 105(6 Part 2):2915-2922.
Issartel, J.-P. et al. (1987) "Is Pyrophosphate an Analog of Adenosine Disphosphate for Beef Heart Mitochondrial F.sub.1 -ATPase" J. Biol. Chem. 262:13538-13544.
Kamijo, K. et al. (1990) "The 70-kDa Peroxisomal Membrane Protein Is a Member of the Mdr (P-glycoprotein)-related ATP-binding Protein Superfamily" J. Biol. Chem. 265(8):4534-4540.
Kerem, B.-S. et al. (1989) "Identification of the Cystic Fibrosis Gene: Genetic Analysis" Science 245:1073-1080.
Kerem, B.-S. et al. (1990) "Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene" PNAS USA 87:8447-8451.
Knowles, M.R. et al. (1991) "Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis" N. Eng. J. Med. 325(8):533-538.
Knowles, M.R. et al. (1990) "A Pilot Study of Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis" N. Eng. J. Med. 322(17):1189-1194.
Ko, Y.H. et al. (1994) "The Cystic Fibrosis Transmembrane Conductance Regulator" J. Biol. Chem. 269:14584-14588.
Kuchler, K. et al. (1989) "Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells" EMBO J. 8(13):3973-3984.
Li, M. et al. (1988) "Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium" Nature 331:358-360.
Marshall, S.E. et al. (1990) "Selection and Evaluation of Recipients for Heart-Lung and Lung Transplantation" Chest 98: 1488-1494.
McElvaney, N.G. et al. (1991) "Aerosol 1-antitrysin treatment for cystic fibrosis" The Lancet 337:392-394.
Michel, L. et al. (1989) "Synthesis and Properties of Azidonitrophenyl Pyrophosphate, a Photoaffinity Probe of Nucleotide Binding Sites of Mitochondrial F.sub.1 -ATPase" Biochem. 28:10022-10028.
Monaco, J.J. et al. (1990) "Transport Protein Genes in Murine MHC: Possible Implications for Antigen Processing" Science 250:1723-1726.
Nagel, G. et al. (1992) "The protein kinase A-regulated cardiac CI.sup.- channel resembles the cystic fibrosis transmembrane conductance regulator" Nature 360:81-84.
Peinnequin, A. et al. (1992) "Does Pyrophosphate Bind to the Catalytic Sites of Mitochondrial F.sub.1 -ATPase?" Biochem. 31(7):2088-2092.
Quinton, P.M. (1990) "Cystic fibrosis: a disease in electrolyte transport" FASEB J. 4:2709-2717.
Reiner, M. et al. (1975) "Le traitment de la maladie de Paget par les diphosphonates (Treatment of Paget's

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