Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2005-11-15
2005-11-15
Weddington, Kevin E. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
active
06964955
ABSTRACT:
Androst-5-ene-3β,17βdiol is used to treat or reduce the likelihood of acquiring osteoporosis or menopausal symptoms, or other diseases affected by estrogen receptor activity, and for conditions which respond well to DHEA treatment, but where a higher ratio of estrogenic to androgenic effects is desired. Combination therapies are included, as are kits and pharmaceutical compositions for providing the active ingredients of claimed methods and combinations.
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Boccuzzi G., et al., “5-ene-androsterone-3beta-17beta-diol inhibits the growth of MCF-7 breast cancer cells when estrogen receptors are blocked by estradiol”,Br J Cancer, Dec. 1994;70(6):1035-9.
Boccuzzi G., et al., “Influence of dehydroepiandrosterone and 5-ene-androsterone-3beta, 17beta-diol on the growth of MCF-7 human breast cancer cells induced by 17beta-estradiol”Anticancer Res, May-Jun 1992; 12(3):799-803.
Endorecherche Inc.
Ostrolenk Faber Gerb & Soffen, LLP
Weddington Kevin E.
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