Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-06-09
1991-03-05
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 514179, 530386, A61K 3704
Patent
active
049978144
ABSTRACT:
Inflammation in mammals is treated by administering anti-inflammatory agent complexed with corticosteroid binding globulin (CBG).
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David-Gwynne, Corticosteroids, p. 446.
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Savu et al.; Corticosterone Binding Globulin: An Acute Phase, "Negative", Protein in the Rat; FEBS Letters (1980); 113: 102-106.
Pugeat et al.; Transport of Steroid Hormones: Interaction of 70 Drugs with Testosterone-Binding Globulin and Cortico-Steroid-Binding Globulin in Human Plasma; Chemical Abstracts (1981); vol. 95.
Pemberton, "Hormone Binding Globulins Undergo Serpin Conformational Change in Inflammation", Nature, vol. 336, Nov. 1988.
Mickelson, et al., Biochemistry, "d-Protein Interactions, Human Corticosteroid Binding Globulin: Physicochemical Properties and Binding Specificity", vol. 20, pp. 6211-6218 (1981).
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Robinson, et al., J. Endocr., "A Solid-Phase Radioimmunoassay for Human Corticosteroid Binding Globulin", vol. 104, pp. 259-267 (1985).
Martindale, The Extra Pharmacopoeia, "Corticosteroids", pp. 446-485 (1982).
Fernlund et al., J. Steroid Biochem., "A Simple Two-Step Procedure for the Simultaneous Isolation of Corticosteroid Binding Globulin and Sex Hormone Binding Globulin from Serum by Chromatography on Cortisol-Sepharose and Phenyl-Sepharose", vol. 14, pp. 545-552 (1981).
Hammond, et al, Proc. Natl. Acad. Sci. USA, "Primary Structure of Human Corticosteroid Binding Globulin, Deduced from Hepatic and Pulmonary cDNAs, Exhibits Homology with Serine Protease Inhibitors", vol. 84, pp. 5153-5157 (1987).
Hammond, et al., Clinical Chimica Acta, "A Versatile Method for the Determination of Serum Cortisol Binding Globulin and Sex Hormone Binding Globulin Binding Capacities", vol. 132, pp. 101-110 (1983).
Brien, Clinical Endocrinology, "Human Corticosteroid Binding Globulin", vol. 14, pp. 193-212 (1981).
Allelix Biopharmaceuticals Inc.
Koh Choon P.
Schain Howard E.
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