Pharmaceutical compositions and their use in the prophylaxis and

Details Pharmaceutical compositions and their use in the prophylaxis and Pharmaceutical compositions and their use in the prophylaxis and

1979-08-10

1981-10-20

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424365, A61K 31055, A61K 4700

Patent

active

042961319

ABSTRACT:
The invention relates to a solvent vehicle for therapeutics comprising a dialkyl ester of adipic acid and, optionally, DMSO, which is particularly useful for therapeutic materials having a low solubility or being insoluble in water.
The invention further relates to pharmaceutical compositions which are suitable for parenteral administration, especially by intramuscular injection, comprising a therapeutically active material dissolved in said solvent vehicle.
Solvent vehicles containing di-n-butyl adipate and DMSO and, if desired, one or more adjuvants, are preferred.
Particularly useful are pharmaceutical compositions for the prophylaxis and/or treatment of diseases caused by internal parasites, which can be administered by intramuscular injection. A preferred embodiment of the invention is an injectable composition against distomatosis (liver fluke disease) containing proportionally 12.5 g 4,6'-dichloro-4',6-dinitro-2,2'-methylenediphenol and 30 g of DMSO, completed with di-n-butyl adipate to 100 cm.sup.3.

REFERENCES:
patent: 2812283 (1957-11-01), Geschickter et al.
patent: 3551554 (1970-12-01), Herschler

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