Pharmaceutical compositions and suppository

Details Pharmaceutical compositions and suppository Pharmaceutical compositions and suppository

1987-06-15

1988-11-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424426, 424423, 424DIG15, A61F 902

Patent

active

047848553

ABSTRACT:
A pharmaceutical composition for suppository which comprises buprenorphine or its pharmaceutically acceptable acid addition salt as the active ingredient and a mixed base composed of 70 to 95 wt. % of polyethylene glycol with average molecular weight of 200 to 20,000 and 30 to 5 wt. % of propylene glycol.

REFERENCES:
patent: 3433791 (1969-03-01), Bentley
patent: 3474101 (1969-10-01), Bentley
patent: 3931187 (1976-01-01), Langbein et al.
patent: 3931189 (1976-01-01), Langbein et al.
patent: 4004010 (1977-01-01), Langbein et al.
patent: 4699776 (1987-10-01), Nishihata et al.
"Preparation of Buprenorphine Suppositories from Commercially Available Injections and Determination of Buprenorphine in the Suppositories", Michiteru Ohtani et al., Yakuzaigaku, vol. 46(3), 229-233 (1986).

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