Pharmaceutical compositions and preparations thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai

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514557, 514974, A61K 3161, A61K 3119

Patent

active

047526068

ABSTRACT:
The invention provides oleanolic acid and/or a physiologically acceptable salt thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced and/or stress-induced.
The invention also provides a pharmaceutical composition comprising an active amount of oleanolic acid and/or a physiologically acceptable salt thereof in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of oleanolic acid in preventing and/or significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.

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patent: 3436454 (1969-04-01), Nouvel
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patent: 3859328 (1975-01-01), Hess
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patent: 4378354 (1983-03-01), Ghyczy et al.
Turner-Screening Methods in Pharmacology, (1965) p. 113 Academic Press, N.Y. & London.
Yamahara et al.-Yakugaku Zasshi, 95 (10), 1179-1182 (1975) English Translation.
Pharmacological Screening Report of "NL-62np" by Panlabs, Inc.
Kato, "Effects of a Stomachic Mixture on Gastric Secretion and Experimental Ulcerations in Rats", Oyo Yakuri Pharmacometrics, vol. 28, No. 5, 901 to 908, 1984.
Shibata, Proc. Asian Symp. Med. Plants Spices, vol. 1, pp. 59-70 (1981).

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