Pharmaceutical compositions and methods using natriuretic...

Details Pharmaceutical compositions and methods using natriuretic... Pharmaceutical compositions and methods using natriuretic...

2005-12-13

2005-12-13

Carlson, Karen Cochrane (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S324000, C514S012200, C514S014800

Reexamination Certificate

active

06974861

ABSTRACT:
The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically. The invention peptides have the formula:R1-Cys-Phe-Gly-Arg- Arg/ - Leu/ -Asp-Arg-                    Lys    Met                                               (1)   Ile- Gly/ -Ser- Leu/ -Ser-Gly-Leu-Gly-Cys-R-2        Ser        Serwherein R1is selected from the group consisting of:                                             (H);                                            Gly-;                                        Ser-Gly-;                                  Asp/                                  Lys/ -Ser-Gly-;                                  Gly                           Arg/   Asp/                           His/ - Lys/ -Ser-Gly-;                           Gln    Gly                           Arg/   Asp/                    Met/ - His/ - Lys/ -Ser-Gly-;                    Val    Gln    Gly                           Arg/   Asp/             Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;             Met    Val    Gln    Gly                           Arg/   Asp/        Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;             Met    Val    Gln    Gly                           Arg/   Asp/    Pro-Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;             Met    Val    Gln    Gly                           Arg/   Asp/Ser-Pro-Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;             Met    Val    Gln    Glyor a 10- to 109-amino acid sequence shown as the native upstream sequence for porcine, canine or human BNP in FIG.8, or a composite thereof;R2is (OH), NH2, or NR′R″ wherein R′ and R″ are independently lower alkyl (1-4C) or isAsn/LysAsn/ -ValLysAsn/ -Val-LeuLysAsn/ -Val-Leu-ArgLysAsn/ -Val-Leu-Arg- Arg/Lys                LysAsn/ -Val-Leu-Arg- Arg/ - Tyr/Lys                Lys    Hisor the amides (NH2or NR′R″) thereof,with the proviso that if formula (1) isR1-Cys-Phe-Gly-Arg-Arg-Leu-Asp-Arg-   Ile-Gly-Ser-Leu-Ser-Gly-Leu-Gly-Cys-R2and R1is Asp-Ser-Gly-, R2cann

Affiliated with

Also associated with

Rating

Pharmaceutical compositions and methods using natriuretic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical compositions and methods using natriuretic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions and methods using natriuretic... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3470364