Pharmaceutical compositions and methods relating to fucans

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S011400, C514S027000, C514S034000, C514S04400A, C514S171000, C514S251000, C514S283000, C514S449000, C514S559000, C514S681000, C514S682000

Reexamination Certificate

active

10958759

ABSTRACT:
Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.

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Bittuon, Patrick, et al., Low-Molecular-Weight Dextran Derivatives (f-CMDB) Enter The Nucleus And Are Better Cell-Growth Inhibitors Compared With Parent CMDB Polymers, Carbohydrate Research, vol. 322, pp. 247-255 (1999).
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Giraux, Jean-Luc, et al., Modulation of Human Endothelial Cell Proliferation and Migration by Fucoidan and Heparin, European J. Cell Biology, vol. 77, pp. 352-359 (1998).
Glabe, Charles G., et al., Reversible Disruption of Cultured Endothelial Monolayers by Sulphated Fucans, J. Cell. Sci., vol. 61, pp. 475-490 (1983).
Itoh, Hiroko, et al., Antitumor Activity and Immunological Properties of Marine Algal Polysaccharides, Especially Fucoidan, Prepared fromSargassum thunbergiiof Phaeophyceae, Anticancer Research, vol. 13, pp. 2045-2052 (1993).
Itoh, Hiroko, et al., Immunological Analysis of Inhibition of Lung Metastases by Fucoidan (GIV-A) Prepared From Brown SeaweedSargassum thunbergii, Anticancer Research, vol. 15, pp. 1937-1948 (1995).
Logearet, Delphine, et al., Fucans, Sulfated Polysaccharides Extracted From Brown Seaweeds, Inhibit Vascular Smooth Muscle Cells Proliferation. I. Comparison With Heparin For Antiproliferative Activity, Binding and Internalization, European J. Cell Biology, vol. 74, pp. 376-384 (1997).
Logearet, Delphine, et al., Fucans, Sulfated Polysaccharides Extracted From Brown Seaweeds, Inhibit Vascular Smooth Muscle Cells Proliferation. II. Degradation and Molecular Weight Effect, European J. of Cell Biology, vol. 74, pp. 385-390 (1997).
Mauray, S., et al., Comparative Ainticoagulant Activity and Influence on Thrombin Generation of Dextran Derivatives and a Fucoidan Fraction, J. Biomater. Sci. polymer. Edn., vol. 9, No. 4, pp. 373-387 (1998).
Nishino, T., et al., Antithrombin Activity of a Fucan Sulfate From The Brown SeaweedEcklonia kurome, Thrombosis Research , vol. 62, pp. 765-773 (1991).
Patankar, Manish S., et al., A revised Structure for Fucoidan May Explain Some of Its Biological Activities, J. Biol. Chem., vol. 268, No. 29, pp. 21770-21776 (1993).
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Shibata, Hideyuki, et al., Inhibitory Effect ofCladosiphonFucoidan on the Adhesion ofHelicobacter pylorito Human Gastric Cells, J. Nutr. Sci. Vitaminol., vol. 45, pp. 325-336 (1999).
Soeda, Shinji, et al., Oversulfated Fucoidan Inhibits the Basic Fibroblast Growth Factor-Induced Tube Formation by Human Umbilical Vein Endothelial Cells: its Possible Mechanism of Action, Biochemica et Biophysica Acta, vol. 1497, pp. 124-134 (2000).
Examination Report for New Zealand Application No. 532015, Apr. 29, 2005.

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