Pharmaceutical compositions and methods of using secreted...

Details Pharmaceutical compositions and methods of using secreted... Pharmaceutical compositions and methods of using secreted...

2006-08-29

2006-08-29

Falk, Anne-Marie (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

C800S018000

Reexamination Certificate

active

07098372

ABSTRACT:
Pharmaceutical compositions and methods of use in regulation of mammalian bone forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts that are important polypeptide growth factors that are known to regulate fundamental biological processes like tissue polarity, embryonic development and tumorigenesis. A SFRP was isolated in human osteoblast cells and identified as SFRP-1 (also known as SARP-2) and shown to be regulated by osteogenic agents in the HOB cells in a differentiation selective manner modulating the life of osteoblasts/preosteocytes.

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