Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-04-04
2006-04-04
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S256000, C514S314000, C514S378000, C514S413000, C514S255050, C544S238000, C544S242000, C544S336000, C546S169000, C546S173000, C546S176000, C546S180000, C546S276700
Reexamination Certificate
active
07022706
ABSTRACT:
Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and disorders associated with dysfunction of the central and autonomic nervous systems can be treated using pharmaceutical compositions incorporating compounds in which an aromatic ring is bridged with an ethylenic or acetylenic unit to an azabicyclic moiety.
REFERENCES:
patent: 5510355 (1996-04-01), Bencherif et al.
patent: 5817679 (1998-10-01), Shen et al.
patent: 5852041 (1998-12-01), Cosford et al.
patent: 5922723 (1999-07-01), Bencherif et al.
patent: 5952339 (1999-09-01), Bencherif et al.
patent: 6022868 (2000-02-01), Olesen et al.
patent: 6060473 (2000-05-01), Shen et al.
patent: 7-61940 (1995-03-01), None
patent: WO 96/06093 (1996-02-01), None
patent: WO 97/11072 (1997-03-01), None
patent: WO 97/13770 (1997-04-01), None
patent: WO 98/54182 (1998-12-01), None
patent: WO 00/44755 (2000-08-01), None
patent: WO 00/58311 (2000-10-01), None
patent: WO 01/32264 (2001-05-01), None
patent: WO 01/49690 (2001-07-01), None
Barlocco, et al., “Mono- and Disubstituted-3-8-diazabicyclo[3.2.1.]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling,” J. Med. Chem, vol. 41, 1998, pp. 674-681.
Cheng, et al., “Synthesis and binding of 6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine and related ring-opened analogs at central nicotinic receptors,” Eur. J. Med. Chem., vol. 34, 1999, pp. 177-190.
Williams, et al., “Neuronal Nicotinic Acetylcholine Receptors,” DN&P, vol. 7, No. 4, May 1994, pp. 205-223.
Badio, et al., “Synthesis and nicotine activity of epiboxidine: an isoxazole analogue of epibatidine,” European Journal of Pharmacology, vol. 321, No. 2, 1997, pp. 189-194.
Olivo, et al., “Syntheses of New Open-Ring and homo-Epibatidine Analogues from Tropinone,” J Org Chem. Jun. 25, 1999;64(13):4966-4968.
Lieske, Spencer F., et al., Substituted Ecgonine Methyl Esters as Inhibitors for Cocaine Binding and Dopamine Uptake, J. Med. Chem. (1998) 41(6), 864-876.
Kozikowski, A. P., et al., Chemistry and Biology of the 2-beta-Alkyl-3-beta-phenyl Analogues of Cocaine: Subnanomolar Affinity Ligands That Suggest a New Pharmacophore Model at the C-2 Position, J. Med. Chem., vol. 38, No. 16, 1995, pp. 3086-3093.
Ran, Yunzhang, et al., Studies on anticholinergics: synthesis of 3-substituted tropane derivatives retrieved from STN, abstract and RN 98042, 91-2 & Yaoxue Xuebao (1984), 19(5), 361-6.
Koh, Jong Sung, et al., Palladium-Mediated Three-Component Coupling Strategy for the Solid-Phase Synthesis of Tropane Derivatives, J. Org. Chem., (1996), 61(14), 4494-4495.
JP 07 061940 A (EISAI) Mar. 7, 1995—English Abstract Only.
Bhatti Balwinder Singh
Clark Thomas Jeffrey
Habte Kahsay
Targacept, Inc.
Womble Carlyle Sandridge & Rice PLLC
LandOfFree
Pharmaceutical compositions and methods for use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions and methods for use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions and methods for use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3573701