Pharmaceutical compositions and methods for use

Details Pharmaceutical compositions and methods for use Pharmaceutical compositions and methods for use

1998-04-02

1999-11-16

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546180, 546 94, 546110, 544242, 544335, C07D22106, C07D40104, C07D40304

Patent

active

059861002

ABSTRACT:
A compound of the formula: ##STR1## wherein X' is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value equal to 0; A, A' and A" are individually substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; Z' is a substituent other than hydrogen; j is an integer from 0 to 5; and the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or a diasteromer; Z" is hydrogen or a substituent other than hydrogen; Y is C.dbd.O, C(OH)R' or C--A, where R' is hydrogen or lower alkyl is provided.

REFERENCES:
patent: 5110933 (1992-05-01), Berlin et al.
patent: 5219849 (1993-06-01), Lotti et al.
patent: 5346906 (1994-09-01), Baker et al.
patent: 5510355 (1996-04-01), Bencherif et al.
patent: 5583140 (1996-12-01), Bencherif et al.
patent: 5684159 (1997-11-01), O'Brien et al.
Nemes et al., "Synthesis and Sterochemistry of 7,9-Disubstituted 3-Azabicyclo[3.3.1]nonaanes," Liebigs Ann. Chem., vol. 2, pp. 179-182, 1993.
Bok et al., "Synthesis and Conformational Analysis of Exo-and Endo-7-Substituted-3-Azabicyclo[3.3.1]nonanes," Tetrahedron, vol. 35, pp. 267-272, 1979.
Hansch et al., "A Survey of Hammett Substituent Constants and Resonance and Field Parameters," Chemical Reviews, vol. 91, pp. 165-195, 1991.
March, "Advanced Organic Chemistry: Reactions, Mechanixms, and Structure", McGraw-Hill: New York, pp. 251-253, 1977.
Becker et al., Synthesis, vol. 11, pp. 1080-1082 (Nov. 1992).
Fernandez et al., J. Heterocycl. Chem., vol. 26, pp. 349-353 (1989).
Lau et al., J. Amer. Chem. Soc., 117, pp. 11421-11425 (1995).
Speckamp et al., Hetercycles, 2, pp. 293-296 (1974).
Holladay et al., J. Med. Chem., vol. 40, No. 26, pp. 4169-4194 (1997).
Henkel et al., J. Org. Chem., 46, pp. 3483-3486 (1981).

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