Pharmaceutical compositions and methods for treating the symptom

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills

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Details

424441, 514810, 514811, 514926, 514927, A61K 920

Patent

active

054179807

ABSTRACT:
This invention relates to a pharmaceutical composition for treating the symptoms of overindulgence comprising an analgesic effective amount of acetaminophen or a non-steroidal anti-inflammatory drug and a gastric acid inhibiting effective amount of an H.sub.1 or H.sub.2 blocker, proton pump inhibitor or a combination thereof and methods of treating the symptoms of overindulgence comprising administering such pharmaceutical compositions.

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Friedman, L. S., and K. J. Isselbacher: Indigestion in Harrison's Principles of Internal Medicine, 11th Edition, 1986, McGraw Hill Book Company, N.Y., pp. 171-175.
Glass, G. B. J. L. Slomiany and A. Slomiany,: Biochemical and Pathological Derangements of the Gastrointestinal Tract following Acute and Chronic Ingestion of Ethanol in Biochemistry and Pharmacology of Ethanol, 1979, Plenum Press, N.Y., vol. 1, pp. 551-586.
Ritchie, J. M.: The Aliphatic Alcohols in Goodman and Gilman, The Pharmacological Basis of Therapeutics, 7th Edition, 1985, MacMillan Publishing Co., N.Y., pp. 375-386.
Lorber, S. H., and V. P. Dimoso, Jr.: Diseases of the Gastrointestinal Tract in The Biology of Alcoholism, vol. 3: Clinical Pathology, 1974 Plenum Press, N.Y., pp. 339-357.
Adams, R. D. and J. B. Martin: Headache in Harrison's Principles of Internal Medicine, 11th Edition, 1986, McGraw Hill Book Company, N.Y., pp. 26-33.
Seegers, A. J. M. L. P. Jager, and J. Van Noordwijk: Effects of Phenacetin Parcetamol and Caffeine on the Erosive Activity of Acetylsalicylic Acid in the Rat Stomach: Dose-Response Relationships, Time Course of Erosion Development and Effects of Acid Secretion, J. Pharm, Pharmacol 31:840-848, 1979.
Stern, A. I., D. L. Hogan, L. H. Kahn, and J. I. Isenberg: Protective Effect of Acetaminophen Against Aspirin--and Ethanol-Induced Damage to the Human Gastric Mucosa. Gastroenterology 86:728-733, 1984.
Deykin, D., P. Janson, and L. McMahon: Ethanol Potentiation of Aspirin-Induced Prolongation of the Bleeding Time. NEJM 306:852-854, 1982.
Unlisted Drugs, vol. 20, No. 11, Nov. 1968, Chatham, N.J., US p. 167, paragraph e: "Infacete".

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