Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-09-19
1999-12-07
Degen, Nancy
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 45, 514 47, 536 276, A01N 4304, C07H 19167
Patent
active
059983868
ABSTRACT:
The present invention is directed to reduce elevated levels of tumor necrosis factor-alpha (TNF-.alpha.) found in a failing heart. The present invention is directed to a composition and method of regulating TNF-.alpha. expression in myocardial tissue by treating the myocardial tissue with biological equivalents of endogenous adenosine. A composition and method of using the composition to treat patients with damaged myocardial tissue is provided which increases the cellular availability of adenosine with a resulting decrease of TNF-.alpha. levels in the heart. The present invention provides a novel pharmacological intervention program in failing mammalian hearts, and more particularly provides a cardioprotective treatment to patients with congestive heart failure.
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Degen Nancy
Miller Raymond A.
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