Pharmaceutical compositions and method of inhibiting H-1 and H-2

Details Pharmaceutical compositions and method of inhibiting H-1 and H-2 Pharmaceutical compositions and method of inhibiting H-1 and H-2

1975-04-16

1976-05-04

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424250, 424251, 424263, 424267, 424269, 424274, 424325, A61K 3154

Patent

active

039549828

ABSTRACT:
Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-methyl-N'-[4-(5)-imidazolyl)butyl]thiourea.

REFERENCES:
patent: 3736331 (1973-05-01), Black et al.
patent: 3808336 (1974-04-01), Durant et al.
patent: 3908014 (1975-09-01), Durant et al.
Black et al., Nature, Vol. 236, Apr. 21, 1972.
Ash et al., J. Pharmac. Chemother, (1966) 27, pp. 427-439.
Kier, J. Med. Chem., (1968), Vol. II, pp. 441-445.

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