Pharmaceutical compositions and method for the production of an

Details Pharmaceutical compositions and method for the production of an Pharmaceutical compositions and method for the production of an

1980-10-06

1983-07-12

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544237, C07D23732, A61K 31495

Patent

active

043930620

ABSTRACT:
This invention relates to enzyme inhibitory, novel phthalazin-4-ylacetic acid derivatives of the general formula I: ##STR1## and pharmaceutically acceptable salts as appropriate, to pharmaceutical compositions thereof, and to analogy processes for their manufacture. The compounds of formula I are inhibitors of the enzyme aldose reductase in vivo and as such may be useful in the reduction or prevention of the development of the peripheral effects such as macular oedema, cataract, retinopathy or impaired neural conduction. A preferred compound is 2-(2-fluoro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic acid.

REFERENCES:
patent: 3833579 (1974-09-01), Inoue et al.
patent: 3864343 (1975-02-01), Inoue et al.
patent: 4066651 (1978-01-01), Brittain et al.
patent: 4096143 (1978-06-01), Sato et al.
patent: 4182876 (1980-01-01), Shimamoto et al.
patent: 4251528 (1981-02-01), Brittain et al.
patent: 4293553 (1981-10-01), Ishikawa et al.
Jour. Khim. Farm Zh vol. 4, cl 22-26 (1970).
Chem. Abstracts vol. 73, p. 366 (77173y) 1970.

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