Pharmaceutical compositions and dosage forms for the oral admini

Details Pharmaceutical compositions and dosage forms for the oral admini Pharmaceutical compositions and dosage forms for the oral admini

1991-01-14

1995-08-15

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530300, 530307, A61K 3823, C07K 14585

Patent

active

054419336

ABSTRACT:
New pharmaceutical compositions containing a calcitonin as active principle and suitable fop opal administration in the form of perbuccal and sublingual tablets ape described, in which the active principle is homogenized with a mixture of solid excipients, said excipients consisting of a diluent, a lubricant, a disintegrating agent in the case of sublingual tablets, and a binder in the case of perbuccal tablets. Said compositions enable the same pattern of hematic levels to be obtained fop the same unit dose as obtainable by conventional intramuscular administration.

REFERENCES:
patent: 4151276 (1979-04-01), Caulin et al.
patent: 4530838 (1985-07-01), Evans et al.
patent: 4663309 (1987-05-01), Kaiser et al.
patent: 5183802 (1993-02-01), Aliverti et al.
patent: 5288497 (1994-02-01), Stanley et al.
Nakada et al., "The Effect of Additives on the Oral Mucosal Absorption of Human Calcitonin in Rats", J. Pharmacobio-Dyn. 11: 395-401, 1988.

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