Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2006-05-22
2009-02-10
Campell, Bruce (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S204100, C424S142100, C424S134100
Reexamination Certificate
active
07488486
ABSTRACT:
A method of reversing a clinical episode of a disease which is generally considered incurable in a subject. The method includes providing an immune-globulin preparation containing a detectable titre of antibodies to the disease which is generally considered incurable and administering the immune-globulin preparation to the subject. Preferably, the immune globulin preparation is a pool of immune globulin fractions gathered from blood of donors living in an area where the disease is endemic. Further disclosed are pharmaceutical compositions and articles of manufacture suited for use in practice of the method.
REFERENCES:
patent: 4665159 (1987-05-01), Dobkin
Shimoni et al., Treatment of West Nile Virus Encephalitis with Intravenous Immunoglobulin, Emerging Infectious Diseases, Letters, Jul. 2001, vol. 7, No. 4, p. 759.
Omr-IgG-am, US Department of Health & Human Servoces Grants Orphan Drug Designation of Immune Globulin (Human) containing high titers of West Nile Virus antibodies for the treatment of the West Nile Virus infection Omr-IgG-am tm.
Roehrig et al., Antibody Prophylaxis and Therapy for Flavivirus Encephalitis Infections, Annals New York Academy Of Sciences, 2001, vol. 951, pp. 286-297.
Dalai et al., Prophylactic and therapeutic effects of human immunoglobulin on the pathobiology of HSV-1 infection, latency, and reactivation in mice, Journal of NeuroVirology. Feb. 2002, vol. 8, pp. 35-44.
Weinberger et al., West Nile Fever Outbreak, Israel, 2000: Epidemiologic Aspects, Emerging Infectious Diseases, Jul. 2001, vol. 7, No. 4, pp. 686-691.
Bulvik Shlomo
Niven Mark Jonathan
Shimoni Zvi
Campell Bruce
Curatolo & Sidoti Co., LPA
Hurt Sharon
Sanz Medical Center-Laniado Hospital
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